[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560003":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":13,"centralContacts":17,"locations":26,"responsibleParty":46,"collaborators":10,"id":48,"slug":10,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"Women with a history of gestational diabetes mellitus",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Women without a history of gestational diabetes mellitus",[14],{"name":15,"affiliation":5,"role":16},"Bettina Mittendorfer, PhD","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Amanda Heider","CONTACT","573-884-6852","ahmc4@health.missouri.edu",{"name":24,"role":20,"phone":10,"phoneExt":10,"email":25},"Vasavi Shabrish, PhD","v.shabrish@missouri.edu",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"University of Missouri School of Medicine","RECRUITING","Columbia","Missouri","65212","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-92.33407,38.95171,{"lat":39,"lon":38},[42],{"name":43,"role":20,"phone":44,"phoneExt":10,"email":45},"Bettina Mittendorfer","573-882-9377","b.mittendorfer@missouri.edu",{"type":16,"investigatorFullName":43,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Senior Associate Dean for Research; Professor, Medicine & Nutrition; NextGen Director of Clinical and Translational Sciences Unit","100560003",false,"NCT06571487","Growth Hormone Resistance of Beta-cells A","Growth Hormone Resistance of Beta-cells in Women With Gestational Diabetes Mellitus","GHRB-A","Inclusion Criteria:\n\n* Singleton, full term pregnancy within the past 5 years\n* Body mass index ≥18.5 kg\u002Fm2 and \\\u003C45.0 kg\u002Fm2\n\nGroup specific inclusion criteria:\n\n* Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy\n* Control Group: no history of gestational diabetes\n\nExclusion Criteria:\n\n* Pregnant, planning to become pregnant during the study, or breastfeeding\n* Current diagnosis or history of type 1 or type 2 diabetes\n* Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)\n* History of bariatric surgery\n* Known, uncontrolled hypothyroidism\n* History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment\n* Current cancer or cancer that has been in remission less than 5 years\n* First degree relative with diabetes diagnosis\n* Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)\n* Alcohol use disorder, use of controlled substances, or smoking \\>2 cigarettes per day\n* Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration\n* Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent",true,"FEMALE","18 Years","45 Years",{"count":60,"type":61},30,"ESTIMATED","OBSERVATIONAL","The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes.",[65,66,67],"Gestational Diabetes","Obesity","Healthy","2026-05-05",{"date":70,"type":71},"2026-05-11","ACTUAL",{"date":73,"type":71},"2025-10-22",{"date":75,"type":61},"2030-09-01",{"name":5,"class":6},1]