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chemo-radiation therapy\n* No tissue sample available for the project, or tumor content in the tissue sample is \\\u003C20%\n* Synchronous colorectal and non-colorectal cancer diagnosed per operative (except skin cancer other than melanoma)\n* Other cancers (excluding colorectal cancer or skin cancer other than melanoma) within 3 years from eligibility screening\n* Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and\u002For otherwise considered by the Investigator to be unlikely to complete the study\n\nColorectal cancer liver metastasis\n\nInclusion Criteria:\n\n* Colorectal cancer liver metastasis\n* Planned for curative-intent treatment\n* Performance status 0-1\n\nExclusion Criteria:\n\n* Liver cirrhosis\n* Extrahepatic metastases\n* Other cancer within the last 5 years\n* Intervention not performed with curative intent\n* No tissue available from CRLM or primary tumor","ALL","18 Years",{"count":281,"type":282},590,"ESTIMATED","OBSERVATIONAL","Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies. Currently, for colorectal cancer, the methods used to decide who gets additional post-surgery treatment are suboptimal. Some patients get too much treatment, while others do not get enough.\n\nThere is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time points.\n\nThe GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient.\n\nGUIDE.MRD-01-CRC is a part of the GUIDE.MRD project.",[286,287],"Colorectal Cancer Stage III","Liver Metastasis Colon Cancer",[289,290,291],"Circulating tumor DNA","ctDNA diagnostics","Minimal residual disease","2026-04-28",{"date":294,"type":295},"2026-05-04","ACTUAL",{"date":297,"type":295},"2023-08-01",{"date":299,"type":282},"2031-07-31",{"name":263,"class":6},15]