HD-tDCS to Modulate Connectivity
ConditionElectricity; Effects
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Manitoba
About this trial
The purpose of the proposed study is to broaden our understanding on the neural effects of High Definition Transcranial Direct Current Stimulation (HD-tDCS) so that its clinical effects can be further improved.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
History or susceptibility to any neurological or psychiatric diseases, particularly seizures
abnormal MRI
metal implants or a cardiac pacemaker
pregnant or breastfeeding women
Trial design
Design model
Parallel
Treatments tested in this trial
high definition transcranial direct current stimulation (HD-tDCS)
DeviceHD-tDCS will be provided for 20 minutes for each stimulation with peak intensity of 2mA.
Treatment groups
100 Participants
are divided into 5 treatment groupsGroup A: left DLPFC stimulationExperimental treatment 1 intervention
Group B: right DLPFC stimulationExperimental treatment 1 intervention
Group C: left IPL stimulationExperimental treatment 1 intervention
Group D: VLPFC-PCC stimulationExperimental treatment 1 intervention
Group E: Sham stimulationSham comparator 1 intervention
Trial outcomes
Primary outcomes
1
change of functional connectivity
Changes in seed-based connectivity originating from the targeted brain regions immediately after the brain stimulation
Time frame
0-11 minutes after the stimulation contrasting baseline (before stimulation)Secondary outcomes
1
change of cerebral blood flow
Changes in Cerebral Blood Flow (estimated using pseudo continuous arterial spin labeling )
Time frame
12-16 minutes after the stimulation contrasting baseline (before stimulation)2
Toronto Mindfulness Scale (curiosity)
mindfulness scale for curiosity. min: 0, max: 30. Higher score means higher curiosity-mindfulness.
Time frame
Baseline, then within 1-2 hours from stimulation3
Toronto Mindfulness Scale (decentering)
mindfulness scale for decentering. min: 0, max: 35. Higher score means higher decentering-mindfulness.
Time frame
Baseline, then within 1-2 hours from stimulationSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Manitoba
Lead sponsor
Natural Sciences and Engineering Research Council, Canada
Collaborator
Source ClinicalTrials.gov