[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644953":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":24,"centralContacts":32,"locations":38,"responsibleParty":54,"collaborators":24,"id":56,"slug":24,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":24,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Split, School of Medicine","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Helichrysum italicum Extract Cream","EXPERIMENTAL","Participants will receive a topical emollient cream containing Helichrysum italicum extract applied to an SLS-treated skin site.",[13],"Other: Helichrysum italicum Extract Cream",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Cream","PLACEBO_COMPARATOR","Participants will receive the same emollient cream base without Helichrysum italicum extract applied to an SLS-treated skin site.",[19],"Other: Placebo Cream",{"label":21,"type":22,"description":23,"interventionNames":24},"Untreated Control Site","NO_INTERVENTION","An SLS-treated skin site that will not receive any topical treatment and will serve as a control for natural skin barrier recovery.",null,[26,29],{"type":6,"name":9,"description":27,"armGroupLabels":28,"otherNames":24},"Topical emollient cream containing Helichrysum italicum extract",[9],{"type":6,"name":15,"description":30,"armGroupLabels":31,"otherNames":24},"A moisturizing cream without Helichrysum italicum extract applied to the designated skin site.",[15],[33],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},"Josipa Bukić","CONTACT","+385917933753","jbukic@mefst.hr",[39],{"facility":40,"status":41,"city":42,"state":24,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"University of Split School of Medicine","RECRUITING","Split","21000","Croatia","HR",{"type":47,"coordinates":48},"Point",[49,50],16.43915,43.50891,{"lat":50,"lon":49},[53],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},{"type":55,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100644953",false,"NCT07676253","Helichrysum Italicum Extract in Irritant Contact Dermatitis","Assessment of the Effect of Helichrysum Italicum Extract in Irritant Contact Dermatitis: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* healthy volunteers who gave written informed consent\n\nExclusion Criteria:\n\n* skin disease\n* skin damage on measurement sites\n* use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial\n* pregnancy or breastfeeding\n* immunosuppression\n* allergic or irritant reactions to the constituents of the cream",true,"ALL","18 Years","50 Years",{"count":67,"type":68},30,"ESTIMATED","INTERVENTIONAL",[71],"NA","The goal of this clinical trial is to evaluate the efficacy and safety of a topical cream containing Immortelle (Helichrysum italicum) extract in promoting skin barrier recovery and reducing signs of irritant contact dermatitis in healthy adult participants.\n\nThe main questions it aims to answer are:\n\n* Does topical application of Helichrysum italicum extract improve skin barrier recovery following experimentally induced irritant contact dermatitis?\n* Does the cream containing Helichrysum italicum extract reduce transepidermal water loss and erythema, and improve skin hydration compared to a standard moisturizing cream?\n* Is the topical application of Helichrysum italicum extract safe and well tolerated?\n\nResearchers will compare skin sites treated with a cream containing Helichrysum italicum extract, placebo-treated skin sites, and untreated skin sites to determine whether the addition of the extract provides additional benefits in skin barrier recovery.\n\nParticipants will:\n\n* Undergo induction of irritant contact dermatitis using sodium lauryl sulfate (SLS) under occlusion.\n* Apply a cream containing Helichrysum italicum extract to one designated skin site and a placebo cream to another designated skin site twice daily throughout the study period.\n* Have an additional SLS-treated skin site left untreated to assess natural skin barrier recovery.\n* Apply the cream containing Helichrysum italicum extract to a separate area of healthy, intact skin.\n* Attend daily study visits for non-invasive assessments of skin barrier function, including transepidermal water loss, skin hydration, and erythema measurements.",[74],"Skin Barrier Disruption and Recovery",[76,77,78,79],"Helichrysum italicum","Immortelle","Irritant contact dermatitis","Skin barrier recovery","2026-06-23",{"date":82,"type":83},"2026-06-30","ACTUAL",{"date":85,"type":68},"2026-06",{"date":87,"type":68},"2027-06",{"name":5,"class":6},1]