Hormonal Control of Energy and Macronutrient Intake in Obesity (MEMORY)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorSteno Diabetes Center Copenhagen
About this trial
The overall aim of the MEMORY study is to examine the concept of 'food memory' - how specific macronutrient compositions influence subsequent food preference and intake, and whether this differs across the BMI range from normal weight to obesity.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18-45 years
For women: Regular menstruation
BMI-range 18.5-39.9 kg/m²
Disqualifiers
Not able or willing to eat or drink the test meals because of e.g., allergy or intolerance
Daily smoking
For women: Pregnancy / planned pregnancy (within the study period) / lactating
Self-reported history of an eating disorder
Trial design
Design model
Crossover
Treatments tested in this trial
High protein liquid test meal
Other interventionHigh protein liquid test meal consisting of whey protein, water and sugar-free coadial mix for flavour.
High carbohydrate liquid test meal
Other interventionHigh carbohydrate liquid test meal consisting of sucrose, water and sugar-free coadial mix for flavour.
Treatment groups
45 Participants
are divided into 2 treatment groupsGroup A: Protein liquid test mealExperimental treatment 1 intervention
Group B: Carbohydrate liquid test mealExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Difference in energy intake from sweet tasting carbohydrates.
The difference in energy intake (E%) from sweet tasting carbohydrates during the ad libitum buffet in response to the high carbohydrate vs. high protein isocaloric liquid test meals.
Time frame
Measured after meal consumption at t=150 minSecondary outcomes
1
Difference in self-reported energy intake
Difference in 24-h self-reported energy intake (KJ) from carbohydrate, protein, and fat and total energy intake in response to the high carbohydrate vs. high protein isocaloric liquid meals.
Time frame
Measured 24-hours after test visits2
Difference in energy intake from fat
Difference in energy intake (KJ) from protein during the ad libitum buffet in response to the high carbohydrate vs. high protein isocaloric liquid meals.
Time frame
Measured after meal consumption at t=150 min3
Difference in energy intake from sweet tasting carbohydrates.
The difference in energy intake (KJ) from sweet tasting carbohydrates during the ad libitum buffet in response to the high carbohydrate vs. high protein isocaloric liquid test meals.
Time frame
Measured after meal consumption at t=150 min4
Difference in energy intake from protein
Difference in energy intake (KJ) from protein during the ad libitum buffet in response to the high carbohydrate vs. high protein isocaloric liquid meals.
Time frame
Measured after meal consumption at t=150 minSponsors and contacts
Click on the lead sponsor to view all of their trials.
Steno Diabetes Center Copenhagen
Lead sponsor
Novo Nordisk A/S
Collaborator
University of Leeds
Collaborator
University of Copenhagen
Collaborator
Source ClinicalTrials.gov