[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641855":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":30,"centralContacts":30,"locations":31,"responsibleParty":50,"collaborators":30,"id":54,"slug":30,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":30,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":91,"whyStopped":30,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"National and Kapodistrian University of Athens","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"INTERVENTION WITH OLIVE OIL EXTRACTS","EXPERIMENTAL","Group of 20 people will receive olive oil extract supplements and after the washout period will receive placebo.",[13],"Dietary Supplement: supplementation, food",{"label":15,"type":10,"description":16,"interventionNames":17},"INTERVENTION WITH BILBERRY","Group of 20 participants will receive bilberry extract supplements and after the washout period a placebo phase.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","supplementation, food","Through this pilot clinical study, the possible change of inflammatory and oxidative stress biomarkers in prediabetic, overweigh\u002F obese people will be observed. Blood, urine and stool samples will be collected, while weight mangment will also be controlled.",[15,9],[25,26,27,28,29],"Body weight and composition changes","oxidative stress and inflammatory biomarkers","blood samples","urine samples","stool samples",null,[32],{"facility":33,"status":30,"city":34,"state":30,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Laiko Hospital","Athens","11527","Greece","GR",{"type":39,"coordinates":40},"Point",[41,42],23.72784,37.98376,{"lat":42,"lon":41},[45],{"name":46,"role":47,"phone":48,"phoneExt":30,"email":49},"NIKOLAOS TENTOLOURIS, PROFESSOR MD, PHD","CONTACT","+30 2132061061","ntentol@meduoa.gr",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Nikolaos Tentolouris","Professor of Medicine","100641855",false,"NCT07659028","Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers.","A Blinded Placebo-controlled Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers. Relevance in European Population","BIOTRANSFORM","Inclusion Criteria:\n\n* 30-50 years old,\n* BMI\\> 25 kg\u002Fm2\n* prediabetic stage\n* hsCRP\\> 2mg\u002F L\n* HbA1c 5,7-6,4%\n* Impaired fasting glucose (IFG)\n* Caucasian\n\nExclusion Criteria:\n\n* No signed informed consent\n* Supplementation or probiotic usage in the past 8 weeks\n* Chronic gastrointestinal, inflammatory or metabolic diseases\n* Alcohol misuse\n* Pregnancy or breastfeeding\n* Acute infection during the past month",true,"ALL","30 Years","50 Years",{"count":66,"type":67},60,"ESTIMATED","INTERVENTIONAL",[70],"NA","Numerous plant-based foods contain bioactive compounds, in particular polyphenols, which have antioxidant, anti-inflammatory, and metabolic regulatory effects. These so-called food bioactives (FB) are converted in the human organism, in particular by the gut microbiota and microsomal (liver\u002Fintestinal) metabolism, into numerous metabolites, which often represent the actual biologically active molecules. As part of the European HORIZON-MSCA Doctoral Network \"BioTransform,\" two such food models are being studied as examples: 1. Olive products (Olea europaea L.) - representative of the Mediterranean diet, rich in secoiridoids and phenylethanols (especially hydroxytyrosol and tyrosol). 2.\n\nBilberry \u002Fblueberry (Vaccinium myrtillus L.) - representative of the Central European diet, rich in anthocyanosides. Two parallel human intervention studies will be conducted, one in Graz (WP1, DC5) and one in Athens (WP1, DC3). These pilot studies will generate biological samples (blood, urine, stool) and investigate the extent to which taking these standardized dietary supplements influences glucose metabolism and markers of oxidative stress and low-grade inflammation.",[73,74,75,76],"Prediabetes","Obesity & Overweight","Inflamation","Oxidative Stress",[78,79,80,81,82,83,84,85,86,87,88,89,90],"FOOD BIOACTIVES","FOOD BIOACTIVE COMPOUNDS","OLIVE PRODUCTS","BILBERRY PRODUCTS","OLEA EUROPEA L.","BILBERRY","VACCINUM MYRTILLOUS L.","GUT MICROBIOME","MICROBIOME MAPPING","IN VITRO","IN SILICO","BIOACTIVE COMPOUNDS","METABOLISM","NOT_YET_RECRUITING","2026-06-15",{"date":94,"type":95},"2026-06-22","ACTUAL",{"date":97,"type":67},"2026-07-01",{"date":99,"type":67},"2029-10-31",{"name":5,"class":6},1]