[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100485848":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":49,"collaborators":23,"id":52,"slug":23,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":23,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":23,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":23,"overallStatus":71,"whyStopped":23,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University of Miami","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Control Group","ACTIVE_COMPARATOR","Individuals without lung disease will receive oxygen for a period of four hours",[13],"Other: Nocturnal Oxygen",{"label":15,"type":10,"description":16,"interventionNames":17},"Nocturnal hypoxemia group","Individuals with lung disease will receive oxygen for a period of four hours",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Nocturnal Oxygen","Nocturnal oxygen will be increased hourly for a period of four hours up to 4 liters per minute (LPM). If the oxygen saturation (SpO2) falls below 70% the oxygen rate will be increased until patients achieve the threshold of 70% and then will proceed with titrations of 1 liter per minute LPM per hour.",[9,15],null,[25],{"name":26,"affiliation":5,"role":27},"Trishul Siddharthan, MD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},"CONTACT","305-243-6388","tsiddhar@miami.edu",[34],{"facility":5,"status":23,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Miami","Florida","33136","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-80.19366,25.77427,{"lat":44,"lon":43},[47,48],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},{"name":26,"role":27,"phone":23,"phoneExt":23,"email":23},{"type":27,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Trishul Siddharthan","Assistant Professor","100485848",false,"NCT05606406","Hypoxia and Heart Rate Variability","Healthy Participants\n\nInclusion Criteria:\n\n• Ability to provide consent\n\nExclusion Criteria:\n\n* BMI \\> 40 kg\u002Fm2\n* Prevalent myocardial infarction, coronary revascularization, heart failure, and stroke\n* Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and\u002For congestive heart failure, uncontrolled blood pressure or resistant hypertension, cancer, and active psychiatric disease (e.g., major depression)\n\nNocturnal Hypoxemia\n\nInclusion Criteria:\n\n* Ability to provide consent\n* Chronic respiratory condition resting Sat \\\u003C 95% off oxygen\n\nExclusion Criteria:\n\n* BMI \\> 40 kg\u002Fm2\n* Prevalent myocardial infarction, coronary revascularization, heart failure, and stroke\n* Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and\u002For congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary disease, cancer, and active psychiatric disease (e.g., major depression)",true,"ALL","18 Years","70 Years",{"count":62,"type":63},70,"ESTIMATED","INTERVENTIONAL",[66],"NA","The purpose of this study is to evaluate how variations in oxygen demands may change heart electrical activity in individuals with and without oxygen dependence.",[69,70],"Pulmonary Disease, Chronic Obstructive","Hypoxia","NOT_YET_RECRUITING","2026-02-02",{"date":74,"type":75},"2026-02-05","ACTUAL",{"date":77,"type":63},"2026-05-30",{"date":79,"type":63},"2027-12-30",{"name":5,"class":6},1]