Health TrialsbyHealthPanel

Hypoxia, Appetite, and Energy Intake in Young Female Adults

ConditionsHypoxiaAltitudeAppetiteEnergy Intake
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-30
SponsorUniversity of Ottawa

About this trial

The goal of this clinical trial is to investigate the effects of acute passive continuous hypoxemia (simulated high-altitude at rest) on appetite and energy intake in healthy young female adults. The main questions it aims to answer are:

* Does six hours of simulated high-altitude (5000 meters) reduce scores of subjective appetite and energy intake? * Do changes in appetite and energy intake persist in the hours following the end of hypoxic exposure? Researchers will compare the effects of simulated high-altitude to a control normoxia (sea-level) condition to see if exposure to low oxygen levels independently affect appetite and energy intake.

Participants will:

* Visit the laboratory for a preliminary screening session to assess eligibility. * Undergo two randomized, single-blind, experimental sessions consisting of six hours of passive exposure to normoxia or hypoxia in a climate-controlled chamber. * Consume foods provided from a curated list, served in ad libitum quantities, after leaving the laboratory to assess post-exposure energy intake.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

English or French speaking

Ability to provide informed consent

Disqualifiers

History or evidence of chronic disease

Current use of hypolipemic medication

Current use of hormonal contraceptives

Current use of antidepressants

Trial design

Design model

Crossover

Treatments tested in this trial

  • Normoxia

    Other intervention

    Participants will undergo a 6-hour passive exposure to normoxia in a climate-controlled environmental chamber maintained at 22°C with 30% relative humidity. They will remain in a fasted state throughout the exposure period.

  • Hypoxia (simulated altitude of 5000 meters above sea-level)

    Other intervention

    Participants will undergo a 6-hour passive exposure to a simulated altitude of 5000 meters above sea-level in a climate-controlled environmental chamber maintained at 22°C with 30% relative humidity. They will remain in a fasted state throughout the exposure period.

Treatment groups

10 Participants
are divided into 2 treatment groups
Group A: NormoxiaExperimental treatment 1 intervention
Group B: Hypoxia (simulated altitude of 5000 meters above sea-level)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change from baseline in desire to eat

Scores of subjective desire to eat, measured using visual analog scales. Measurements are performed upon arrival at the laboratory (baseline), hourly during the exposure, immediately after a 30-minute ad libitum buffet, immediately before bedtime, and 24 hours after the baseline measurement.

Time frame
Baseline and 6 hours; Baseline and 24 hours
2

Change from baseline in hunger

Scores of subjective hunger, measured using visual analog scales. Measurements are performed upon arrival at the laboratory (baseline), hourly during the exposure, immediately after a 30-minute ad libitum buffet, immediately before bedtime, and 24 hours after the baseline measurement.

Time frame
Baseline and 6 hours; Baseline and 24 hours
3

Change from baseline in fullness

Scores of subjective fullness, measured using visual analog scales. Measurements are performed upon arrival at the laboratory (baseline), hourly during the exposure, immediately after a 30-minute ad libitum buffet, immediately before bedtime, and 24 hours after the baseline measurement.

Time frame
Baseline and 6 hours; Baseline and 24 hours
4

Change from baseline in prospective food consumption

Scores of subjective prospective food consumption, measured using visual analog scales. Measurements are performed upon arrival at the laboratory (baseline), hourly during the exposure, immediately after a 30-minute ad libitum buffet, immediately before bedtime, and 24 hours after the baseline measurement.

Time frame
Baseline and 6 hours; Baseline and 24 hours

Secondary outcomes

1

Heart rate

Measured continuously throughout the exposure.

Time frame
6 hours
2

Oxyhemoglobin saturation

Measured continuously throughout the exposure.

Time frame
6 hours
3

Systolic blood pressure

Measured upon arrival at the laboratory (baseline), hourly during the exposure, and immediately after eating.

Time frame
6 hours
4

Diastolic blood pressure

Measured upon arrival at the laboratory (baseline), hourly during the exposure, and immediately after eating.

Time frame
6 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Ottawa

Lead sponsor

Natural Sciences and Engineering Research Council, Canada

Collaborator

Hopital Montfort

Collaborator

Institut du Savoir Montfort

Collaborator

Source ClinicalTrials.gov
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