[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541511":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":20,"centralContacts":35,"locations":41,"responsibleParty":59,"collaborators":61,"id":64,"slug":20,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":20,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":44,"whyStopped":20,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University Hospital Tuebingen","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Moyamoya patients","EXPERIMENTAL","Newly diagnosed Moyamoya patients who will follow a standardized imaging and biosampling protocol. Possible surgical or conservative treatment will not be influenced by this study.",[13,14,15],"Diagnostic Test: MRI","Diagnostic Test: H2 15O PET\u002FCT","Other: Biosampling",{"label":17,"type":18,"description":19,"interventionNames":20},"Control group","NO_INTERVENTION","Healthy patients and patients with intracerebral atherosclerotic disease are used as comparators for the results of biosampling.",null,[22,27,31],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":20},"DIAGNOSTIC_TEST","MRI","Patients will get special MRI sequences (CO2-triggered BOLD MRI, Vessel-wall imaging, resting state BOLD MRI) to identify cerebral vasoreactivity and disease activity.",[9],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":20},"H2 15O PET\u002FCT","Patients will get H2 15O PET\u002FCT with acetazolamide challenge to define the cerebral vasoreserve for comparison with fMRI Images",[9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":20},"Biosampling","Patients do get a venous puncture for blood analysis on circulating endothelial cells and virus PCR analysis",[9],[36],{"name":37,"role":38,"phone":39,"phoneExt":20,"email":40},"Constantin Roder, Prof. Dr., MD","CONTACT","0049-7071290","constantin.roder@med.uni-tuebingen.de",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"University of Tuebingen, Neurosurgery","RECRUITING","Tübingen","Baden-Wurttemberg","72076","Germany","DE",{"type":51,"coordinates":52},"Point",[53,54],9.05222,48.52266,{"lat":54,"lon":53},[57],{"name":37,"role":38,"phone":58,"phoneExt":20,"email":40},"07071-290",{"type":60,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[62],{"name":63,"class":6},"University Hospital Freiburg","100541511",false,"NCT06330818","Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients","IMAGINE - Imaging in Moyamoya Disease","IMAGINE","Inclusion Criteria:\n\n* Patients with suspicion of Moyamoya Disease\n* Patients able to understand the study and to give their informed consent\n\nExclusion Criteria:\n\n* Cerebral vascular disease caused by atherosclerosis\n* Vasculitis\n* Contraindications to MRI\n* Contraindications to PET\u002FCT\n* Pregnancy\n* Inability to give informed consent\n* Renal insufficiency",true,"ALL","18 Years","80 Years",{"count":76,"type":77},50,"ESTIMATED","INTERVENTIONAL",[80],"NA","Aim of this study is to improve patient care in Moyamoya Patients by improving Imaging technologies and aiming to identify factors involved in disease progression.\n\nMain tasks are:\n\n* Analysis of CO2-triggered BOLD fMRI for analysis of cerebral hemodynamics in comparison to H2 15O PET\u002FCT\n* Analysis of longitudinal changes of contrast enhancement in vessel-wall imaging and correlation of disease activity with biosampling\n* Definition of a standardized recommendation for pre- and postoperative imaging of Moyamoya patients",[83,84],"Moyamoya Disease","Moyamoya",[86,84,87],"Stroke","EC-IC Bypass","2024-09-25",{"date":90,"type":91},"2024-09-26","ACTUAL",{"date":93,"type":91},"2024-07-01",{"date":95,"type":77},"2027-11-30",{"name":5,"class":6},1]