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Immunomodulatory Effects of NB-UVB and Steroids in Vitiligo: A Study on CXCL11 and TEMRA Biomarkers

ConditionsVitiligoNB-UVB
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorAssiut University

About this trial

this is a prospective, randomized controlled trial (RCT) investigating the immunological effects of narrowband UVB (NB-UVB) phototherapy-both as monotherapy and in combination with oral mini-pulse (OMP) steroids-in non-segmental vitiligo patients. The study evaluates changes in CXCL11 (a chemokine involved in T-cell recruitment) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA) levels in serum before and after treatment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • NB-UVB twice weekly

    Radiation

    Standard phototherapy without additional systemic treatment.

  • NB-UVB + dexamethasone (2.5-3 mg/week)

    Other intervention

    Combination therapy to enhance immunosuppression and repigmentation.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Group 1 (NB-UVB Monotherapy)Experimental treatment 1 intervention
Group B: Group 2 (NB-UVB + OMP Steroids)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in serum CXCL11 & TEMRA levels

Measured via ELISA before and after treatment.

Time frame
6 months

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: