[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100372296":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":10,"locations":34,"responsibleParty":59,"collaborators":10,"id":62,"slug":10,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Roma La Sapienza","OTHER",[8,12,15,20],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with non-functioning adrenal adenoma",null,"Patients with incidentally discovered adrenal mass with 1mg-DST serum cortisol levels lower than 50 nmol\u002FL",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients with pACS receiving conservative management","Patients with incidentally discovered adrenal mass with 1mg-DST serum cortisol levels greater than 50 nmol\u002FL receiving conservative management",{"label":16,"type":10,"description":17,"interventionNames":18},"Patients with pACS receiving adrenalectomy","Patients with incidentally discovered adrenal mass with 1mg-DST serum cortisol levels greater than 50 nmol\u002FL receiving adrenalectomy according to the 2016 European Society of Endocrinology guidelines",[19],"Procedure: Adrenalectomy",{"label":21,"type":10,"description":22,"interventionNames":10},"Healthy controls","Patients without adrenal masses",[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"PROCEDURE","Adrenalectomy","Adrenalectomy according to 2016 ESE guidelines",[16],[30],{"name":31,"affiliation":32,"role":33},"Andrea M Isidori, MD, PHD","Sapienza","PRINCIPAL_INVESTIGATOR",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":39,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Department of Experimental Medicine","RECRUITING","Rome","Italy","00161","IT",{"type":43,"coordinates":44},"Point",[45,46],12.51133,41.89193,{"lat":46,"lon":45},[49,54,57],{"name":50,"role":51,"phone":52,"phoneExt":10,"email":53},"Andrea M Isidori, MD, PhD","CONTACT","+390649970711","andrea.isidori@uniroma1.it",{"name":55,"role":56,"phone":10,"phoneExt":10,"email":10},"Marianna Minnetti","SUB_INVESTIGATOR",{"name":58,"role":56,"phone":10,"phoneExt":10,"email":10},"Emilia Sbardella",{"type":33,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Andrea M. Isidori","Full Professor of Endocrinology","100372296",false,"NCT04127552","Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations","Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study)","ITACA","Inclusion Criteria:\n\n* Incidentally detected adrenal mass\n\nExclusion Criteria:\n\n* Patients with overt Cushing's syndrome, pheochromocytoma, Conn syndrome, adrenocortical carcinoma, late-onset congenital adrenal hyperplasia, adrenal metastasis and adrenal hemorrhage\n* Patients taking medications influencing glucocorticoid production or metabolism\n* Patients with psychiatric diseases or alcohol abuse\n* Pregnancy",true,"ALL","18 Years","80 Years",{"count":74,"type":75},68,"ESTIMATED","OBSERVATIONAL","The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS). Investigators hypothesize that adrenalectomy in selected patients, following the 2016 European Congress of Endocrinology (ECE) guidelines, can improve metabolic parameters and cardiovascular risks and features.",[79,80,81],"Adrenal Incidentaloma","Hypercortisolism","Adrenal Tumor","2025-03-24",{"date":84,"type":85},"2025-03-28","ACTUAL",{"date":87,"type":85},"2019-01-02",{"date":89,"type":75},"2025-12-31",{"name":5,"class":6},1]