Impact of Depression on Thermoregulation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-40
SponsorPenn State University
About this trial
The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Non-depressed adults aged 18-40 years;
OR adults aged 18-40 years with clinically diagnosed major depressive disorder according to DSM-V criteria not currently receiving antidepressant treatment;
OR adults aged 18-40 years with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a selective serotonin reuptake inhibitor;
OR aged 18-40 years adults with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a serotonin norepinephrine reuptake inhibitor;
Disqualifiers
BMI > 35
Are pregnant or planning to become pregnant in the next 12 months;
Concurrently participate in another study involving physical activity or weight loss;
Plan to have surgery or relocate outside the area within the next year;
Trial population
Participants will be recruited from Centre County Pennsylvania including on the Penn State University campus.
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
64 Participants
are grouped into 4 trial groupsGroup A: Non-depressed
Group B: Depressed
Group C: SSRI
Group D: SNRI
Trial outcomes
Primary outcomes
1
Skin blood flow
Skin blood flow response to whole body heating is continuously monitored during the experimental trial, about 2 hours.
Time frame
Monitored continuously during the passive heating experimental trial, about 2 hours.2
Local Sweat Rate
A small sweat capsule is placed on the forearm for the duration of the passive whole body heating experiment, about 2 hours.
Time frame
Monitored continuously during the passive heating experimental trial, about 2 hours.3
Core Temperature
Changes in body temperature are measured through a telemetry pill swallowed before each experiment.
Time frame
Monitored continuously during the passive heating experimental trial, about 2 hours.Secondary outcomes
1
Body Mass
Body mass is measured on a scale before and after the passive heating experimental trail.
Time frame
Will be measured once immediately before and once immediately after the passive heating experimental trail.Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov