[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620484":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":51,"collaborators":28,"id":55,"slug":28,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":28,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":80,"whyStopped":28,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Damascus University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"St. Thomas' cardioplegia","ACTIVE_COMPARATOR","Intervention: Patients in this group will be managed with St. Thomas' cold crystalloid cardioplegia solution during surgery",[13],"Procedure: The intervention is the use of a specific cardioplegia solution for myocardial protection",{"label":15,"type":10,"description":16,"interventionNames":17},"Calafiore cardioplegia","Patients in this group will be managed with Calafiore warm blood intermittent cardioplegia solution during surgery",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"del Nido cardioplegia","Patients in this group will be managed with del Nido cold blood intermittent cardioplegia solution during surgery",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","The intervention is the use of a specific cardioplegia solution for myocardial protection","Three different solutions will be used for myocardial protection in this study, and will be compared using markers of myocardial injury",[15,9,19],null,[30],{"name":31,"affiliation":32,"role":33},"Mohammad B Izzat, FRCS(CTh)","Damascus University School of Medicine","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":28,"email":39},"Mohamad B Izzat, FRCS(CTh)","CONTACT","+963943240820","mbizzat@damascusuniversity.edu.sy",{"name":41,"role":37,"phone":42,"phoneExt":28,"email":43},"Mohammad S Hamra, MD","+963949889467","mbizzat@gmail.com",[45],{"facility":46,"status":28,"city":47,"state":48,"zip":49,"country":50,"countryCode":28,"cosmosGeoPoint":28,"geoPoint":28,"contacts":28},"Damascus University Cardiac Surgery Hospital","Damascus","Rif-dimashq Governorate","Rawda","Syria",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","Mohammad Bashar Izzat","Professor","100620484",false,"NCT07358221","Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery","Impact of Different Cardioplegia Solutions on Extracellular Vesicles-derived miRNAs, Complement System, and Neutrophil Extracellular Traps (NETs) as Indicators of Myocardial Injury During Coronary Artery Bypass Surgery","Cardioplegia2","Inclusion Criteria:\n\n* All consecutive patients undergoing elective primary coronary artery bypass grafting will be enrolled in this study.\n\nExclusion Criteria:\n\n* Patients will be excluded from this study if they had suffered from previous myocardial infarction, had reduced ejection fraction or were undergoing combined or repeated surgery","ALL","40 Years","75 Years",{"count":66,"type":67},30,"ESTIMATED","INTERVENTIONAL",[70],"NA","The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St. Thomas' cold crystalloid cardioplegia, Calafiore warm blood cardioplegia, or modified del Nido cold blood cardioplegia in routine coronary artery bypass grafting procedures.",[73,74],"Coronary Artery Bypass Grafting (CABG) Surgery","Myocardial Protection",[76,77,78,79],"coronary surgery","cardioplegia","complement activation","myocardial injury","NOT_YET_RECRUITING","2026-01-14",{"date":83,"type":84},"2026-01-22","ACTUAL",{"date":86,"type":67},"2026-02",{"date":88,"type":67},"2027-02",{"name":5,"class":6},1]