Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-42
SponsorKhyber Medical University Peshawar

About this trial

This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.

Eligibility criteria

Qualifiers

Age 18 to 42 years.

Diagnosed with fatty liver (NAFLD) via imaging (e.g., ultrasound).

Liver fibrosis assessed and staged via FibroScan and the FIB-4 index.

Literate (to consent and complete cognitive assessments/questionnaires).

Disqualifiers

History of alcohol intake >20g/day.

Chronic viral hepatitis B or C.

Major neuropsychiatric illnesses.

Pregnancy or breastfeeding.

Trial design

Treatments tested in this trial

  • Structured Mediterranean Diet
  • Control / General Advice

Treatment groups

45 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Khyber Medical University Peshawar

Lead sponsor

Northwest General Hospital and Research centre

Collaborator

Khyber Teaching Hospital

Collaborator