[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100508929":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":23,"centralContacts":30,"locations":37,"responsibleParty":55,"collaborators":23,"id":59,"slug":23,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":23,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":23,"maxAge":23,"enrollmentInfo":67,"targetDuration":23,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":23,"overallStatus":40,"whyStopped":23,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Catania","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Peri-implantitis","EXPERIMENTAL","Subjects diagnosed with peri-implantitis according to the most recent international guidelines and without cardiovascular diseases.",[13],"Procedure: Non-surgical periodontal treatment",{"label":15,"type":16,"description":17,"interventionNames":18},"Peri-implant mucositis","ACTIVE_COMPARATOR","Subjects diagnosed with peri-implant mucositis according to the most recent international guidelines and without cardiovascular diseases.",[13],{"label":20,"type":21,"description":22,"interventionNames":23},"Healthy","NO_INTERVENTION","Subjects without periodontitis and with good gingival health.",null,[25],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":23},"PROCEDURE","Non-surgical periodontal treatment","Subgingival biofilm ultrasonic debridement",[15,9],[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Gaetano Isola, PhD","CONTACT","+39-095-378-2453","CT","gaetano.isola@unict.it",[38],{"facility":39,"status":40,"city":41,"state":23,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"AOU Policlinico G. Rodolico","RECRUITING","Catania","95124","Italy","IT",{"type":46,"coordinates":47},"Point",[48,49],15.07041,37.49223,{"lat":49,"lon":48},[52],{"name":53,"role":33,"phone":54,"phoneExt":23,"email":23},"Gaetano Isola, DDS","+3909537800",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Gaetano Isola","Researcher","100508929",false,"NCT05906810","Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis","Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis: a Randomized-controlled Clinical Trial.","PERI-IMPLANTITIS GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with peri-implantitis according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.\n\nPERI-IMPLANT MUCOSITIS GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with peri-implant mucositis according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.\n\nHEALTHY GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with healthy periodontum withouth periodontitis history according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Scaling, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.",true,"ALL",{"count":68,"type":69},90,"ESTIMATED","INTERVENTIONAL",[72],"NA","A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis\u002Fperi-implant mucositis and without any cardiovascular disease.",[75,76,77,78],"Atherosclerosis","Endothelial Dysfunction","Peri-Implantitis","Peri-implant Mucositis","2025-05-18",{"date":81,"type":82},"2025-05-21","ACTUAL",{"date":84,"type":82},"2020-10-05",{"date":86,"type":69},"2025-12-20",{"name":5,"class":6},1]