[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637018":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":61,"collaborators":30,"id":64,"slug":30,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":30,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":45,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Type 1 diabetes - normal weight","ACTIVE_COMPARATOR","Type 1 diabetes normal weight",[13],"Other: Exercise training",{"label":15,"type":10,"description":16,"interventionNames":17},"Control - normal weight","healthy control - normal weight",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Overweight control","Overweight, otherwise healthy",[13],{"label":23,"type":10,"description":23,"interventionNames":24},"Type 1 diabetes - overweight",[13],[26],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Exercise training","15 weeks of HIIT exercise training",[15,19,9,23],null,[32],{"name":33,"affiliation":5,"role":34},"Zhenqi Liu, MD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Lee Hartline, MEd","CONTACT","434-924-5247","lmh9d@virginia.edu",{"name":33,"role":38,"phone":30,"phoneExt":30,"email":42},"zl3e@UVAhealth.org",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Charlottesville","Virginia","22908","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-78.47668,38.02931,{"lat":55,"lon":54},[58,59,60],{"name":33,"role":38,"phone":39,"phoneExt":30,"email":42},{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},{"name":33,"role":34,"phone":30,"phoneExt":30,"email":30},{"type":34,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Zhenqi Liu","Associate Professor","100637018",false,"NCT07573228","Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes","Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes (","ZQL010","Inclusion Criteria:\n\n* • Male or female ≥21 and ≤50 years old\n\n  * For persons with T1D: Disease duration ≥ 5 years and HbA1c ≤ 8.5% on multiple daily insulin injection or insulin pump\n  * Body mass index: ≥19 and ≤27 kg\u002Fm2 for control and T1D, ≥30 and ≤40 kg\u002Fm2 (27.5 to 37.5 for Asian Americans) for obesity and T1D + obesity. BMI is limited to ≤40 kg\u002Fm2 (37.5 for Asian Americans) for easier vascular access and cardiac imaging.\n  * Stable use of non-insulin medications for over 6 months other than estrogen\u002Fprogesterone containing medications which must be discontinued at least 3 months prior to the study (intrauterine devices may be continued due to limited systemic absorption)\n\nExclusion Criteria:\n\n* • Acute or chronic disease other than T1D or obesity\n\n  * History of microvascular or macrovascular diabetes complications\n  * History of diabetic ketoacidosis in the past 24 months\n  * History of hypoglycemia unawareness\n  * Recently active (\\>20 min of moderate\u002Fhigh intensity exercise, 2 times\u002Fweek)\n  * Subjects who are smokers or who have quit smoking \\\u003C5 years\n  * Subjects with hypertriglyceridemia (\\>400 mg\u002Fdl)\n  * Current use of vasoactive medications (i.e. calcium channel blockers, angiotensin-converting enzyme or renin inhibitors, angiotensin-receptor blockers, nitrates, alpha- or beta-blockers, or diuretics).\n  * Females taking oral contraceptives in the past 3 months\n  * Subjects with a history of significant metabolic, cardiac, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or malignancy\n  * Pregnant (as evidenced by positive pregnancy test) or nursing women\n  * Musculoskeletal condition preventing participation in exercise testing or exercise training\n  * History of gastroparesis\n  * Pulse oximetry \\\u003C90%",true,"ALL","21 Years","50 Years",{"count":76,"type":77},60,"ESTIMATED","INTERVENTIONAL",[80],"NA","The purpose of this study is:\n\n* To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program.\n* To see if being overweight and having Type 1 diabetes is associated with lower cardio fitness compared to overweight healthy controls, before and after a HIIT exercise program.",[83,84],"Type 1 Diabetes","Overweight",[86,27,87,88],"Type 1 diabetes","healthy controls","overweight","2026-05-01",{"date":91,"type":92},"2026-05-07","ACTUAL",{"date":94,"type":92},"2026-02-23",{"date":96,"type":77},"2030-06-30",{"name":5,"class":6},1]