[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544009":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":32,"responsibleParty":50,"collaborators":52,"id":55,"slug":25,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":25,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":25,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":34,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Skidmore College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dietary Capsaicin","EXPERIMENTAL","Over-the-counter dose of 2 x 440 mg capsules (880 mg, Capsicum Pepper Blend, Daily Manufacturing, Rockwell, North Carolina, USA)",[13],"Dietary Supplement: Dietary capsules",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","The placebo will be 2 x 400-500 mg fiber (800 mg psyllium husk) capsules which were chosen to be of similar appearance (size, coloration, and texture).",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Dietary capsules","Daily doses of dietary capsaicin or placebo in capsule form",[9,15],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Stephen Ives, PhD","CONTACT","5185808366","sives@skidmore.edu",[33],{"facility":5,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Saratoga Springs","New York","12866","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-73.78457,43.08313,{"lat":44,"lon":43},[47],{"name":48,"role":29,"phone":49,"phoneExt":25,"email":31},"Stephen Ives, Ph.D.","518-580-8366",{"type":51,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[53],{"name":54,"class":6},"American Heart Association","100544009",false,"NCT06363305","Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health","Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health: A Randomized Controlled Trial","Inclusion Criteria:\n\n* relatively healthy (other than elevated blood pressure) non-smoking men and women over the age of 18 from the local community\n\nExclusion Criteria:\n\n* Women who are without a period (not due to a birth control method, intrauterine device or menopause), are pregnant, attempting to conceive, or are breastfeeding will be excluded.\n* uncontrolled hypertension\n* Anyone with severe illness or compromised or suppressed immune system (e.g. taking immune suppressants, chronic viral infection or treatment).\n* Any participants with excessive sensitivity to spicy foods or fiber (psyllium husk) will be excluded\n* Participants with food allergies will be excluded\n* Participants who have difficulty swallowing or swallowing pills may be excluded.\n* Participants who suffer from heartburn, hiatal hernia, gastritis, or peptic ulcer disease may be excluded.",true,"ALL","18 Years",{"count":65,"type":66},80,"ESTIMATED","INTERVENTIONAL",[69],"NA","The investigators long-term goal is to better understand novel interventions to promote cardiovascular health in humans. The goal of the proposed research is to investigate whether there is sex-specificity in the effects of dietary capsaicin on mechanisms regulating nitric oxide (NO) bioavailability, its effect on key markers of cardiovascular (CV) health, including BP, macro- and microvascular function, and arterial stiffness. This knowledge will provide critical insight into the effects of dietary capsaicin on CV health and will guide future trials.",[72,73],"Pre Hypertension","Hypertension",[75,76,77],"vascular stiffness","blood pressure","vascular function","2024-07-08",{"date":80,"type":81},"2024-07-10","ACTUAL",{"date":78,"type":81},{"date":84,"type":66},"2025-12-31",{"name":5,"class":6},1]