[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541072":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":51,"collaborators":25,"id":54,"slug":25,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":25,"eligibilityCriteria":58,"healthyVolunteers":55,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":25,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":25,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Meyer Children's Hospital IRCCS","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with SSNS","EXPERIMENTAL","Patients with SSNS and patients undergoing renal transplantation for NS with post-transplant disease recurrence will be enrolled for serum sampling for the study of immunological and\u002For permeabilizing factors (including anti-nephrin antibodies).",[13],"Diagnostic Test: Anti-nephrin antibodies",{"label":15,"type":10,"description":16,"interventionNames":17},"Patients with SRNS undergoing genetic testing by WES","Patients with SRNS undergoing genetic testing by WES and variant prioritization will undergo serum sampling for the study of immunologic and\u002For permeabilizing factors (including the anti-nephrin antibodies), and urine sampling for u-RPC cultures.",[13,18],"Diagnostic Test: u-RPC cultures",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","Anti-nephrin antibodies","Assessment of anti-nephrin antibodies on serum samples and in vitro study of permeabilizing effect on 3D organ-on-a-chip models and STED microscopy on healthy human kidneys.",[15,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"u-RPC cultures","Urine sample collection for u-RPC cultures",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Paola Romagnani, Prof, MD, PhD","CONTACT","055 5662562","paola.romagnani@meyer.it",[37],{"facility":5,"status":38,"city":39,"state":25,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Florence","Italy","IT",{"type":43,"coordinates":44},"Point",[45,46],11.24626,43.77925,{"lat":46,"lon":45},[49],{"name":50,"role":33,"phone":25,"phoneExt":25,"email":25},"Paola Romagnani",{"type":52,"investigatorFullName":50,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Professor, MD, PhD","100541072",false,"NCT06325098","Implementation of a Diagnostic Workflow for Personalized Diagnosis of Nephrotic Syndrome","Inclusion Criteria:\n\n* Clinical diagnosis of NS (SSNS, SRNS, or NS relapsed after transplantation regardless of initial response to steroid therapy)\n* Age below 40 years at disease onset\n* Availability of clinical information\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Age at onset above 40 years\n* Kidney biopsy proving lesions other than FSGS and MCD","ALL","1 Month","40 Years",{"count":63,"type":64},150,"ESTIMATED","INTERVENTIONAL",[67],"NA","Nephrotic syndrome (NS) is a clinical picture common to several diseases resulting from damage to podocytes and glomerular filtration barrier. Currently, there is limited consensus regarding the diagnostic pathway and management of the specific etiology. Some patients show complete response to first-line steroid therapy (steroid-sensitive nephrotic syndrome, SSNS), especially in children and young adults. The prognosis of this group is generally favorable. In contrast, patients unresponsive to steroids (steroid-resistant NS, SRNS) frequently undergo immunosuppressive therapies, which are burdened with numerous side effects. Resistance to treatment is associated with a high likelihood of progression to chronic renal disease (CKD) and kidney failure (ESKD). Recent evidence suggests that immunological mechanisms (including permeabilizing factors) are involved in the pathogenesis of post-transplant NS recurrence and SSNS.\n\nProviding patients with NS with a correct diagnosis is the cornerstone of personalized medicine, reducing morbidity and side effects of therapies, ensuring their appropriate prescription, and slowing or preventing progression to ESKD.",[70],"Nephrotic Syndrome","2024-03-15",{"date":73,"type":74},"2024-03-22","ACTUAL",{"date":76,"type":74},"2022-01-26",{"date":78,"type":64},"2026-06-30",{"name":5,"class":6},1]