[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595431":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":34,"responsibleParty":74,"collaborators":78,"id":84,"slug":23,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":23,"eligibilityCriteria":89,"healthyVolunteers":85,"sex":90,"minAge":91,"maxAge":23,"enrollmentInfo":92,"targetDuration":23,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":104,"overallStatus":36,"whyStopped":23,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University of Miami","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Core","Clinics in this arm will receive strategies that involve capacity building for nurses and education on mental health.",[12],"Other: Core Implementation Strategies",{"label":14,"type":6,"description":15,"interventionNames":16},"Enhanced","Clinics in the enhanced arm will receive core strategies along with enhanced strategies that involve more intensive training on depression treatment.",[12,17],"Other: Enhanced Implementation Strategies",[19,24],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Core Implementation Strategies","* Task Sharing\u002FRevise Professional Roles\n* Distribute educational materials\u002FDynamic Training\u002FAddress Stigma\n* Clinician Implementation Team Meetings\n* Partner with CoCT DoH\n* Champion\n* Audit and Feedback\n* Stage Scale Up\u002FTailoring",[9,14],null,{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Enhanced Implementation Strategies","* Train the trainer\n* Ongoing supervision and consultation",[14],[29],{"name":30,"role":31,"phone":32,"phoneExt":23,"email":33},"Steven A Safren, PhD","CONTACT","305-243-3471","ssafren@miami.edu",[35,54,64],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Miami","Florida","33136","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-80.19366,25.77427,{"lat":46,"lon":45},[49,50],{"name":30,"role":31,"phone":32,"phoneExt":23,"email":33},{"name":51,"role":31,"phone":52,"phoneExt":23,"email":53},"Marc Puccinelli, PhD","305-243-3508","mpuccinelli@miami.edu",{"facility":55,"status":36,"city":56,"state":57,"zip":58,"country":40,"countryCode":41,"cosmosGeoPoint":59,"geoPoint":63,"contacts":23},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":43,"coordinates":60},[61,62],-71.05977,42.35843,{"lat":62,"lon":61},{"facility":65,"status":36,"city":66,"state":23,"zip":23,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":73,"contacts":23},"University of Cape Town","Cape Town","South Africa","ZA",{"type":43,"coordinates":70},[71,72],18.42322,-33.92584,{"lat":72,"lon":71},{"type":75,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Steven Safren","Professor",[79,82,83],{"name":80,"class":81},"National Institute of Mental Health (NIMH)","NIH",{"name":55,"class":6},{"name":65,"class":6},"100595431",false,"NCT07032363","Implementing Depression and Adherence Treatment","Implementing Depression and Adherence Treatment in South Africa HIV Care","Inclusion Criteria for Clinics (the primary \"participants\"):\n\n* Clinics are eligible if they provide HIV primary care via the City of Cape Town (CoCT) Department of Health\n* Clinics will be assigned to the study upon notice of funding and before start up.\n\nInclusion Criteria for Patient-level Outcomes:\n\nAlthough the unit of randomization is at the clinic level, the study will be looking at adult patient level data at each clinic. All patients engaged in care at one of the 10 primary care\u002FHIV treatment clinics in the study will be included if they:\n\n* Are 18 years of age or older and\n* Have a detectable HIV viral load (operationalized as the lower limit of detection on the standard test is used at the local clinic), or presumed detectable viral load per clinic standards\n* Screen in for depression via the PHQ (following detection standards set in clinics)\n\nExclusion Criteria:\n\n-Children below the age of 18 will not be included in the proposed study for adults.","ALL","18 Years",{"count":93,"type":94},10,"ESTIMATED","INTERVENTIONAL",[97],"NA","The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The main questions it aims to answer are:\n\nWhat proportion of patients start an evidence-based treatment for depression (reach)? What percentage of patients show clinical improvement in depression and what percentage attain viral undetectability within one year (effectiveness)?\n\nResearchers will compare high and low reach clinics to further inform tailored implementation strategies for uptake and maintenance.\n\nClinics will be randomized into one of two study arms: core versus enhanced strategies. In both arms, core strategies will be utilized. Enhanced clinics will also receive more resource-intensive training.",[100,101,102,103],"Depression","HIV","Adherence, Treatment","AIDS",[105,101,106],"implementation science","depression","2026-06-22",{"date":109,"type":110},"2026-06-24","ACTUAL",{"date":112,"type":110},"2026-05-20",{"date":114,"type":94},"2030-05",{"name":5,"class":6},3]