About this trial
The goal of this project is to establish the technical feasibility of a scalable, integrated platform to improve patient informed decision-making and increase vaccine uptake and to evaluate the effectiveness of the integrated platform to improve vaccine uptake.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patient has an upcoming appointment in 2 business days at Children's Healthcare of Atlanta Hughes Spalding Primary Care Clinic.
A valid mobile phone number or e-mail address is available in the EHR as of 2 business days prior to the appointment date.
Due for a COVID-19 vaccine based on Epic Systems© COVID-19 vaccine health maintenance topic.
Due for any vaccines based on Epic Systems© implementation using health maintenance topics of the Centers for Disease Control CDS for Immunization (CDSi) specifications.
Disqualifiers
None
Trial design
Parallel
Treatments tested in this trial
LetsTalkShots (patient-facing CDS)
Other interventionLetsTalkShots is a website which provides patients/parents with tailored videos addressing vaccine concerns.
LetsTalkShots (provider-facing CDS)
Other interventionThe provider-facing CDS component will propagate patient concerns obtained from LetsTalkShots (and the appropriate talking points to address the talking points) into the electronic health record (EHR) for the provider at the point of care.
Appointment Reminder Message
Other interventionThe regular text message and e-mail appointment reminder includes a vaccine primer (e.g. "Vaccines are due and reserved for the participant's child"), but no patient- or provider-facing CDS.
Treatment groups
Trial outcomes
Primary outcomes
Vaccination rate
Proportion of vaccines due that are administered at the index appointment
Secondary outcomes
Days undervaccinated
The sum of all days during which the child was undervaccinated for 1 or more doses of any vaccine(s). Undervaccination begins (per Lumen et al) starting 1 month after the initial due date of a vaccine (e.g. if a patient has not yet received a 2-month vaccine, then days undervaccinated begin accumulating when the child turns 3 months old).
Patient Adoption as assessed by proportion of successful texts sent
Proportion of successfully sent text messages with links to patient-facing CDS that are clicked on and have questionnaires answered.
Provider Adoption as assessed by proportion of orders opened
Proportion of provider-facing best practice advisory (BPA) alerts in which the provider opens the order set for all vaccines due.
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Johns Hopkins Bloomberg School of Public Health
Lead sponsor
Children's Healthcare of Atlanta
Collaborator
Emory University
Collaborator
Merck Sharp & Dohme LLC
Collaborator