Improving Vaccine Acceptance Through EHR Integrated Patient- and Provider-Facing Decision Support

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorJohns Hopkins Bloomberg School of Public Health

About this trial

The goal of this project is to establish the technical feasibility of a scalable, integrated platform to improve patient informed decision-making and increase vaccine uptake and to evaluate the effectiveness of the integrated platform to improve vaccine uptake.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patient has an upcoming appointment in 2 business days at Children's Healthcare of Atlanta Hughes Spalding Primary Care Clinic.

A valid mobile phone number or e-mail address is available in the EHR as of 2 business days prior to the appointment date.

Due for a COVID-19 vaccine based on Epic Systems© COVID-19 vaccine health maintenance topic.

Due for any vaccines based on Epic Systems© implementation using health maintenance topics of the Centers for Disease Control CDS for Immunization (CDSi) specifications.

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • LetsTalkShots (patient-facing CDS)

    Other intervention

    LetsTalkShots is a website which provides patients/parents with tailored videos addressing vaccine concerns.

  • LetsTalkShots (provider-facing CDS)

    Other intervention

    The provider-facing CDS component will propagate patient concerns obtained from LetsTalkShots (and the appropriate talking points to address the talking points) into the electronic health record (EHR) for the provider at the point of care.

  • Appointment Reminder Message

    Other intervention

    The regular text message and e-mail appointment reminder includes a vaccine primer (e.g. "Vaccines are due and reserved for the participant's child"), but no patient- or provider-facing CDS.

Treatment groups

1,200 Participants
are divided into 4 treatment groups
Group A: Patient- and Provider-Facing CDSExperimental treatment 3 interventions
Group B: Patient-Facing CDS OnlyExperimental treatment 2 interventions
Group C: Control (MYchart account)Placebo comparator 1 intervention
Group D: Control (no MYchart account)Placebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Vaccination rate

Proportion of vaccines due that are administered at the index appointment

Time frame
Baseline

Secondary outcomes

1

Days undervaccinated

The sum of all days during which the child was undervaccinated for 1 or more doses of any vaccine(s). Undervaccination begins (per Lumen et al) starting 1 month after the initial due date of a vaccine (e.g. if a patient has not yet received a 2-month vaccine, then days undervaccinated begin accumulating when the child turns 3 months old).

Time frame
Through 24 months of age
2

Patient Adoption as assessed by proportion of successful texts sent

Proportion of successfully sent text messages with links to patient-facing CDS that are clicked on and have questionnaires answered.

Time frame
Up to one year
3

Provider Adoption as assessed by proportion of orders opened

Proportion of provider-facing best practice advisory (BPA) alerts in which the provider opens the order set for all vaccines due.

Time frame
Up to one year

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Johns Hopkins Bloomberg School of Public Health

Lead sponsor

Children's Healthcare of Atlanta

Collaborator

Emory University

Collaborator

Merck Sharp & Dohme LLC

Collaborator