[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556553":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":57,"collaborators":26,"id":60,"slug":26,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":26,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PMI-targeted group","EXPERIMENTAL","The participants will be treated according to the standard of care for mechanical ventilation. During PSV, pressure support is set and adjusted according to the PMI target.",[13],"Procedure: PMI-targeted pressure support setting and adjustment",{"label":15,"type":16,"description":17,"interventionNames":18},"VT\u002FRR-targeted group","ACTIVE_COMPARATOR","The participants will be treated according to the standard of care for mechanical ventilation. During PSV, pressure support is set and adjusted according to the VT\u002FRR target.",[19],"Procedure: VT\u002FRR-targeted pressure support setting and adjustment",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","PMI-targeted pressure support setting and adjustment","During PSV, the pressure support is set and adjusted to a PMI target between 0 and 2 cmH2O.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"VT\u002FRR-targeted pressure support setting and adjustment","During PSV, pressure support is set and adjusted according to a VT\u002FRR target of VT between 6 and 8 ml\u002Fkg predicted body weight, RR between 20 and 35 breaths\u002Fmin, and no signs of respiratory distress.",[15],[32],{"name":33,"affiliation":5,"role":34},"Jian-Xin Zhou, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","8610 6392 6666","zhoujx.cn@icloud.com",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Beijing Shijitan Hospital","RECRUITING","Beijing","Beijing Municipality","100038","China","CN",{"type":50,"coordinates":51},"Point",[52,53],116.39723,39.9075,{"lat":53,"lon":52},[56],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"type":34,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Jian-Xin Zhou","Professor","100556553",false,"NCT06526598","Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial","A Cluster Randomized Trial on Inspiratory Effort-Based Pressure Support Adjustment Strategy in Patients Undergoing Assisted Mechanical Ventilation","IT-PSV","Mechanically ventilated patients, who are admitted to the ICU with acute hypoxic respiratory failure, will be consecutively screened daily at 08:00-10:00 morning rounds.\n\nInclusion criteria:\n\n1. PSV initiated during the last 24 hours;\n2. Mechanical ventilation expected to be required for at least 24-48 h by responsible physicians;\n3. The partial pressure of oxygen in arterial blood (PaO2)\u002Finspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure PEEP);\n4. No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.\n\nExclusion criteria included:\n\n1. Age younger than 18 years old;\n2. Initiation of PSV before ICU admission;\n3. Duration of mechanical ventilation longer than 7 days before enrollment;\n4. History of neuromuscular diseases;\n5. Clinical suspicion of increased intracranial pressure;\n6. Extracorporeal support;\n7. Moribund conditions;\n8. Refusal by the ICU physicians or the patient.","ALL","18 Years",{"count":70,"type":71},619,"ESTIMATED","INTERVENTIONAL",[74],"NA","The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to the traditional tidal volume and respiratory rate target, can improve clinical outcomes in adult participants undergoing pressure support ventilation.\n\nThe investigators propose a physiological-oriented assisted ventilation management that, if found effective, could potentially change the clinical practice for mechanical ventilation.",[77,78,79],"Critical Care","Acute Hypoxic Respiratory Failure","Ventilator-Induced Lung Injury",[81,82,83],"pressure support ventilation","pressure muscle index","inspiratory effort","2026-01-19",{"date":86,"type":87},"2026-01-21","ACTUAL",{"date":84,"type":87},{"date":90,"type":71},"2027-02-28",{"name":5,"class":6},1]