[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100467619":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":26,"responsibleParty":45,"collaborators":47,"id":50,"slug":10,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Develop Persistent Postsurgical Pain",null,"Pain present 3 months post-op related to the surgical operation",{"label":13,"type":10,"description":14,"interventionNames":10},"Absence of Persistent Postsurgical Pain","Resolution of post-operative pain within the first three months of the operation",[16],{"name":17,"affiliation":18,"role":19},"Sibtain Anwar, MBBS MA PhD","Barts Health NHS Trust & Queen Mary University of London","STUDY_CHAIR",[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Brian Herath, MBBS","CONTACT","00447870681640","b.herath@nhs.net",[27],{"facility":28,"status":29,"city":30,"state":10,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"St Bartholomew's Hospital","RECRUITING","London","EC1A 7BE","United Kingdom","UK",{"type":35,"coordinates":36},"Point",[37,38],-0.12574,51.50853,{"lat":38,"lon":37},[41,42],{"name":22,"role":23,"phone":10,"phoneExt":10,"email":25},{"name":43,"role":23,"phone":10,"phoneExt":10,"email":44},"Sibtain Anwar","s.anwar@qmul.ac.uk",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48],{"name":49,"class":6},"Barts & The London NHS Trust","100467619",false,"NCT05369130","Investigate and Predict Aortic & Thoracic Surgery Persistenet Postsurgical Pain","Characterising the Phenotype for Persistent Postoperative Pain Following Repair of the Thoraco-abdominal Aorta","ImPARTonPPP","Inclusion Criteria:\n\n* Adults (over 18 years of age) undergoing elective repair of the thoraco-abdominal aorta. Able to adequately understand and respond to verbal instructions\n\nExclusion Criteria:\n\n* Unwilling or unable to give consent, Age \\\u003C18 years","ALL","18 Years",{"count":60,"type":61},60,"ESTIMATED","OBSERVATIONAL","This is an observational clinical study aiming to further the wider understanding of patients who develop persistent pain after Thoracoabdominal Aorta surgery, a surgical cohort who are disproportionately affected. This will be undertaken through a prospective biopsychosocial characterisation of the phenotype of patients undergoing this operation.\n\nIncreasing numbers of patients are undergoing surgery on the chest for treatment of heart or lung cancer disease. Over the last twenty years, the medical community has become increasingly aware of the long-term effect of this surgery in producing persistent pain, approximately half of all survivors are still in pain around their surgical incision at three months postoperatively and beyond. There is currently no accepted method for preventing this phenomenon.\n\nThe nervous system mechanisms for the development of persistent pain after surgery are unclear. Some studies suggest it may involve the patient's ability to dampen down pain signals travelling from the incision site to the brain.\n\nHumans have an in-built system that produces opiates as well as other pain-relieving molecules in response to injury, e.g. surgery. However, this response varies hugely from person to person and may even be impacted by the psychological state of the individual at the time of surgery. Some of these pain modulating mechanisms can be measured before and after surgery in patients using sensory testing, a robust and established objective method to assess patients'.\n\nIdentifying patients who are most at risk of a persistent pain state will allow both academics and clinicians to investigate and better target appropriate treatments.\n\nUndertaking these longitudinal observational assessments will facilitate an improved mechanistic insight of the transition from acute to pathological pain, with the ultimate goal of improving outcomes for patients'.",[65],"Persistent Postsurgical Pain","2026-03-13",{"date":68,"type":69},"2026-03-16","ACTUAL",{"date":71,"type":69},"2022-06-12",{"date":73,"type":61},"2029-02",{"name":5,"class":6},1]