[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643622":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":26,"id":58,"slug":26,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":26,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Tianjin Anding Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"active","ACTIVE_COMPARATOR","The peak-to-peak amplitude was 1 mA at 40 Hz (tACS), with a frequency and a sinusoidal stimulation waveform. The stimulation sites were located in the prefrontal cortex (F3 and F4) based on the 10-20 international EEG electrode placement system, with CZ serving as the return electrode.",[13],"Device: Transcranial Alternating Current Stimulation (tACS)",{"label":15,"type":16,"description":17,"interventionNames":18},"shame","SHAM_COMPARATOR","The peak-to-peak amplitude was 1 mA at 40 Hz (tACS), with a frequency and a sinusoidal stimulation waveform. The stimulation sites were located in the prefrontal cortex (F3 and F4) based on the 10-20 international EEG electrode placement system, with CZ serving as the return electrode, shame arm is not biologically active.",[19],"Device: shame tACS",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcranial Alternating Current Stimulation (tACS)","divided into a real-stimulus group and a sham-stimulus group",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"shame tACS","The sham tACS group received 40 Hz tACS with a peak-to-peak amplitude of 1 mA, a frequency of y, and a sinusoidal waveform. The stimulation sites were located in the prefrontal cortex (F3 and F4) based on the 10-20 system of international EEG electrode placement, with CZ serving as the return electrode, which did not generate stimulation pulses.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Daliang Sun Da liang Sun, Doctor","CONTACT","+86 88188876","474929588@qq.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Tianjin","Tianjin Municipality","300222","China","CN",{"type":46,"coordinates":47},"Point",[48,49],117.17667,39.14222,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":35,"phoneExt":26,"email":36},"Daliang Sun, Doctor",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Jie Li","Chief psychiatrist","100643622",false,"NCT07637773","Investigating the Efficacy and Mechanisms of Individualized tACS Targeting Anhedonia in Late-Life Depression","Efficacy and Mechanisms of Personalized tACS Targeting Anhedonia in Late-Life Depression","Inclusion Criteria:\n\n* (1) Patients were interviewed using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) - Clinical Version (SCID-5-CV) to confirm that they met the DSM-5 diagnostic criteria for \"major depressive disorder\"; (2) Age ≥ 60 years; gender not restricted; (3) Hamilton Depression Scale (HAMD)-17 score \\> 24\n\nExclusion Criteria:\n\n\\- (1) History of severe head trauma or serious neurological conditions such as epilepsy; (2) Any brain devices or implants, including cochlear implants and aneurysm clips; treatments such as transcranial direct current stimulation (tDCS).\n\n(3) Individuals who have undergone other physical modulation therapies within the past 8 weeks, including but not limited to non-convulsive electroconvulsive therapy, repetitive transcranial magnetic stimulation, and transcranial direct current stimulation.","ALL","60 Years",{"count":67,"type":68},80,"ESTIMATED","INTERVENTIONAL",[71],"NA","This project focuses on clinical translational research into personalized transcranial alternating current stimulation (tACS) for treating anhedonia in late-life depression (LLD). Key components include: (1) Optimizing individualized tACS treatment parameters through randomized, double-blind, controlled trials and establishing precise treatment protocols using deep learning algorithms; (2) Assessing the short-term (2 weeks) and long-term (3 months) efficacy of tACS on depressive symptoms and anhedonia using scales such as the HAMD, SHAPS, and DARS, while monitoring safety; (3) Integrating multimodal detection technologies (64-channel EEG, inflammatory factors\u002Fneurotransmitters, etc.) to elucidate the mechanisms by which tACS alleviates anhedonia through modulating prefrontal neural oscillations (y-band), improving synaptic plasticity (increased BDNF), and regulating neurotransmitters (5-HT, DA). This study will establish, for the first time, an individualized parameter system for tACS treatment of LLD, providing a novel non-pharmacological intervention strategy for clinical practice.",[74,75],"Late-Life Depression","Anhedonia",[77,78,79,80],"transcranial alternating current stimulation","late-life depression","anhedonia","Brain function","2026-06-09",{"date":83,"type":84},"2026-06-10","ACTUAL",{"date":86,"type":84},"2026-03-16",{"date":88,"type":68},"2027-12-31",{"name":56,"class":6},1]