Health TrialsbyHealthPanel

Involvement of Archaea in Carious Disease

ConditionDental Caries
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssistance Publique Hopitaux De Marseille

About this trial

Dental caries is a major public health probleme the result of hard tissue demineralization and oral microbiota changes.

Methanogenic archaea, mainly Methanobrevibacter oralis, are associated with various oral problems, including pathologies periodontal.

Previous research has not really studied the Archaea in carious lesions, hence the importance of our study.

Our study aims to explore their potential role in the the development of caries by analysing their prevalence and their quantification in relation to the carious risk individual. The aim is to improve understanding of the Cavity microbiology to advance management of this pathology in terms of prevention or of treatment.

Our team is particularly competent in the field of Archaea, especially in the cultivation of Archaea methanogens since we have a dedicated platform. We also discovered the first human Nanoarchaea, opening up a whole new possible search field.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Male or female of legal age.

Patient who is a beneficiary or entitled beneficiary of a social security

Patient under the care of the Restorative and Preventive Dentistry of the PROMOD - Timone Dentistry Unit.

Patients capable of giving written consent.

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • saliva sample

    Other intervention

    saliva sample

  • carious tissue samples

    Other intervention

    carious tissue samples

Treatment groups

200 Participants
are divided into 2 treatment groups
Group A: low risk of carriagesExperimental treatment 1 intervention
Group B: high risk for caries.Other 2 interventions

Trial outcomes

Primary outcomes

1

Presence/absence of Archaea in participants' saliva samples.

Time frame
36 months

Secondary outcomes

1

Quantity of Archaea in the salivary sample of the participants.

Time frame
36 months
2

Viability/non-viability of Archaea in carious lesions

Time frame
36 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assistance Publique Hopitaux De Marseille

Lead sponsor

Source ClinicalTrials.gov
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