iPACK Block vs. Periarticular Infiltration for TKA Pain Control
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorTurgutlu State Hospital
About this trial
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA). The primary purpose is to evaluate whether a combination of two specific nerve blocks administered by an anesthesiologist (Femoral Triangle Block + iPACK block) resulted in superior postoperative pain control compared to a hybrid combination of a nerve block and a local infiltration administered by the surgeon (FTB + Periarticular Infiltration \[PAI\]).
The hypothesis is that the FTB + iPACK combination is associated with a significant reduction in Numeric Rating Scale (NRS) pain scores with movement at 24 hours postoperatively. This is a retrospective, observational cohort study conducted at a single center, involving medical records of patients who underwent primary unilateral TKA. Data from patients who received either FTB + iPACK or FTB + PAI as part of their standard clinical care will be extracted and analyzed retrospectively.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
American Society of Anesthesiologists (ASA) physical status II-III.
Scheduled for elective, primary, unilateral total knee arthroplasty for osteoarthritis.
Able to provide written informed consent.
Disqualifiers
Patient refusal to participate or contraindication to regional anesthesia.
Known allergy to any study medications (local anesthetics, NSAIDs, tramadol, morphine, paracetamol).
History of chronic opioid use (defined as daily use for >3 months)
Pre-existing peripheral neuropathy in the operative limb.
Trial population
The study population consists of adult patients who underwent elective, primary, unilateral total knee arthroplasty (TKA) under spinal anesthesia at Turgutlu State Hospital. Patient records and institutional registries will be reviewed retrospectively to identify eligible cases managed within a specific operational period (e.g., between December 2025 and May 2026). The cohort includes patients who received either an ultrasound-guided Femoral Triangle Block combined with an iPACK block or a hybrid combination of Femoral Triangle Block and surgeon-administered Periarticular Infiltration for postoperative analgesia as part of standard clinical care.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
100 Participants
are grouped into 2 trial groupsGroup A: FTB + iPACK Group
Group B: FTB + PAI Group
Trial outcomes
Primary outcomes
1
Postoperative Pain Score with Movement at 24 Hours
Pain assessed via Numeric Rating Scale (NRS) during active movement (e.g., active knee flexion or straight leg raise). Scale: 0 (no pain) to 10 (worst pain imaginable).
Time frame
24 and 48. hours postoperativelySecondary outcomes
1
Postoperative Pain Scores (Time-Course)
Numeric Rating Scale (NRS) for pain (0-10) assessed at rest and with movement.
Time frame
Assessed at 6, 12, and 24 hours postoperatively2
Time to First Rescue Analgesia
Time (in minutes) from the end of surgery to the first patient request for rescue tramadol.
Time frame
First 24 postoperative hours3
Time Up to Go Test
The time taken (in seconds) for the participant to stand up from a standard armchair, walk a distance of 3 meters, turn, walk back to the chair, and sit down. Lower values indicate better functional mobility.
Time frame
Assessed at 24 hours4
Straight Leg Raise
Assessment of active quadriceps motor function. Defined as the participant's ability to actively lift the operated leg off the bed with the knee fully extended (straight). This will be assessed as a binary outcome (Success = Able to lift unassisted / Failure = Unable to lift).
Time frame
Postoperative 24. hourSponsors and contacts
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Source ClinicalTrials.gov
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