[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634683":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":38,"responsibleParty":54,"collaborators":56,"id":60,"slug":24,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":40,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Pennington Biomedical Research Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Normobaric hypoxia (NH)","EXPERIMENTAL","8 weeks of overnight exposure (8 hrs\u002Fnight) to NH conditions (\\~15% oxygen; achieved with nitrogen dilution, equivalent to \\~8500 feet elevation) using a commercially available tent and generator system (Hypoxico, Inc., New York, NY).",[13],"Other: Normobaric hypoxia (NH)",{"label":15,"type":16,"description":17,"interventionNames":18},"Normobaric normoxia (NN)","SHAM_COMPARATOR","8 weeks of overnight exposure (8 hrs\u002Fnight) to NN conditions (\\~21% oxygen; sea level) using a commercially available tent and generator system (Hypoxico, Inc., New York, NY).",[19],"Other: Normobaric normoxia (NN)",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Low oxygen exposure to mimic \\~8500 feet elevation (experimental)",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Normal oxygen exposure to mimic sea level conditions (sham comparator).",[15],[29],{"name":30,"affiliation":5,"role":31},"Camila Weschenfelder, PhD","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},"Recruitment Core","CONTACT","225-763-3000","clinicaltrials@pbrc.edu",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Baton Rouge","Louisiana","70808","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-91.18747,30.44332,{"lat":50,"lon":49},[53],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},{"type":55,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[57],{"name":58,"class":59},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100634683",false,"NCT07542873","Iron Absorption in The Low Oxygen Exposure and Weight Status (LOWS) Study","Effects of Energy Restriction and Intermittent Hypoxia on Iron Absorption in Obesity","LOWS-IRON","Inclusion Criteria:\n\n* Obese (BMI between 30-39.9 kg\u002Fm2)\n* Born at altitudes below 2,100 meters (\\~7,000 feet)\n* Currently residing in Baton Rouge, Louisiana or surrounding area\n* Not taking any medication(s) that interfere with oxygen delivery\u002Ftransport for 4 weeks prior to and throughout the entire study (e.g., includes sedatives, sleeping aids, tranquilizers and\u002For any medication that depresses ventilation, diuretics, alpha and beta blockers).\n* Willing to refrain from smoking, vaping, chewing tobacco, and dietary supplement use throughout the entire study.\n* Willing to have a hypoxic tent set-up in their home and spend 8 consecutive hours per night in the tent for 8 weeks\n\nExclusion Criteria:\n\n* Living in areas that are more than 1,200 m (\\~4,000 feet), or have traveled to areas that are more than 1,200 m for five days or more within the last 2 months\n* Cardiovascular abnormalities, gastrointestinal disorders, or any condition that interferes with oxygen delivery\u002Ftransport (e.g., kidney disease, cardiovascular disease, etc.)\n* Oxygen saturation \\\u003C 95% while awake or oxygen saturation dips below 88% for a total of ≥ 10 min overnight in normoxic conditions\n* Evidence of apnea or other sleeping disorders\n* Evidence of prior high-altitude pulmonary edema (HAPE) or high-altitude cerebral edema (HACE) diagnosis\n* Diagnosis or family history of sickle cell anemia\u002Ftrait\n* Hematocrit \\\u003C42% for males, \\\u003C36% for females\n* Hemoglobin \\\u003C13 g\u002FdL for males, \\\u003C12 g\u002FdL for females\n* Blood donation within 8 weeks of beginning the study\n* Present condition of alcoholism, anabolic steroids, or other substance abuse issues\n* Women who are pregnant, lactating, planning to become pregnant, or who have had an irregular menstrual cycle in the past 6 mo.\n* Weight gain or loss \\> 10% of body weight during the past 6 months\n* Adults unable to consent","ALL","22 Years","65 Years",{"count":71,"type":72},30,"ESTIMATED","INTERVENTIONAL",[75],"NA","Declines in iron status are common in those with obesity and may be due to obesity-related chronic inflammation; however, the effects of reducing inflammation following diet-induced weight loss on iron metabolism are poorly understood. Low environmental oxygen exposure increases dietary iron absorption and availability to supply iron for erythropoiesis but has not yet been tested in the context of weight loss. This study is designed to investigate diet-induced weight loss (inflammation reduction) and overnight low oxygen exposure (erythropoiesis stimulating agent) as strategies to improve dietary iron absorption in obesity.",[78],"Obesity (Disorder)",[80,81,82,83,84,85,86],"Body weight","Normobaric hypoxia","Negative energy balance","Energy intake","Energy expenditure","Iron absorption","Iron metabolism","2026-04-14",{"date":89,"type":90},"2026-04-21","ACTUAL",{"date":92,"type":90},"2025-04-21",{"date":94,"type":72},"2026-06-30",{"name":5,"class":6},1]