[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567640":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":12,"id":55,"slug":12,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":12,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":12,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":78,"whyStopped":12,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"National Defense Medical Center, Taiwan","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Active iTBS for Patients With MCI or AD","ACTIVE_COMPARATOR","The patient will receive one daily rTMS session for 10 days of iTBS, delivered through an H-coil applied to the left dorsolateral prefrontal cortex. The TBS frequency parameters consist of 3-pulse 50-Hz bursts every 200 ms at 5 Hz, and the intensity will be set at 80% of the active motor threshold (AMT). A single session of iTBS contains 2 s of TBS repeated every 10 s for 20 times.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Sham iTBS for Patients With MCI or AD","SHAM_COMPARATOR","Sham stimulation will be delivered 10 sessions.",[18],"Device: Sham rTMS",[20,24],{"type":21,"name":22,"description":23,"armGroupLabels":12,"otherNames":12},"DEVICE","Active rTMS","iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions",{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":12},"Sham rTMS","sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions",[14],[29],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},"YU-KAI LIN","CONTACT","886-987-859-907","yukai0907@ndmctsgh.edu.tw",[35],{"facility":36,"status":12,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Tri-Service General Hospital","Taipei","Other","114","Taiwan","TW",{"type":43,"coordinates":44},"Point",[45,46],121.52639,25.05306,{"lat":46,"lon":45},[49,52],{"name":50,"role":31,"phone":51,"phoneExt":12,"email":33},"Yu-Kai Lin","886-2-87923311 ext 10552,13907",{"name":12,"role":31,"phone":32,"phoneExt":12,"email":12},{"type":54,"investigatorFullName":50,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","100567640",false,"NCT06670820","iTBS in MCI and Mild AD","The Effects of Intermittent Theta-burst Stimulation on Cognitive Function in Patients With Mild Cognitive Impairment and Mild Alzheimer's Disease and the Role of Brain-Derived Neurotrophic Factor","Inclusion Criteria:\n\n* Clinical diagnosis of MCI (overall Clinical Dementia Rating of 0.5)\n* Clinical diagnosis of mild Alzheimer's Disease (overall Clinical Dementia Rating of 0.5 or 1)\n\nExclusion Criteria:\n\n* History of stroke\n* History of uncontrol seizure\n* History of significant head trauma followed by persistent neurologic deficit or known structural brain abnormality\n* Mental illness\n* Drug abuse","ALL","50 Years","85 Years",{"count":65,"type":66},80,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.",[72,73],"Mild Cognitive Impairment (MCI)","Mild Alzheimer Disease",[75,76,77,73],"rTMS","iTBS","Mild Cognitive Impairment","NOT_YET_RECRUITING","2024-10-31",{"date":81,"type":82},"2024-11-01","ACTUAL",{"date":79,"type":66},{"date":85,"type":66},"2028-12-31",{"name":5,"class":6},1]