This retrospective observational single-center study aims to evaluate the medical and occupational relevance of systematic screening for latent tuberculosis infection using QuantiFERON-TB Gold Plus during pre-employment occupational health assessment among hospital workers at the University Hospital of Nice. Data will be collected retrospectively from occupational health medical records, immunology laboratory results and, when necessary, data from specialized follow-up by the tuberculosis control center. The primary objective is to determine the proportion of positive QuantiFERON-TB Gold Plus tests at pre-employment screening. Secondary objectives are to identify factors associated with a positive test, to describe the practical consequences of screening, including chest X-ray, diagnosis of latent tuberculosis infection and initiation of preventive treatment, and to estimate the cost of systematic screening.
Newly recruited hospital workers at the University Hospital of Nice.
Workers who underwent pre-employment occupational health assessment during the study period.
Workers who had a QuantiFERON-TB Gold Plus test performed as part of pre-employment screening.
Known history of active tuberculosis disease before employment.
Previously known latent tuberculosis infection before employment.
Incomplete or unusable occupational health records.
Indeterminate QuantiFERON-TB Gold Plus results will be included in the descriptive analysis but excluded from comparative analyses of test positivity.
The study population consists of newly recruited hospital workers at the University Hospital of Nice who underwent pre-employment occupational health assessment and QuantiFERON-TB Gold Plus screening during the study period. The population includes medical, paramedical, medico-technical, administrative, technical, logistical, transport and support staff, with or without direct patient contact.
Cohort
Retrospective
QuantiFERON-TB Gold Plus
Diagnostic testRetrospective analysis of QuantiFERON-TB Gold Plus results performed as part of routine pre-employment occupational health screening. No additional diagnostic test or intervention will be performed for the purpose of the study.
Percentage of positive QuantiFERON-TB Gold Plus tests at pre-employment screening
Percentage of positive QuantiFERON-TB Gold Plus
Association between risk factors and positive QuantiFERON-TB Gold Plus test
Variables collected included age, sex, country of birth, previous stay in a high tuberculosis-incidence area, prior contact with tuberculosis, immunosuppression status, occupational category, and direct patient contact
Percentage of workers with clinical follow-up after positive QuantiFERON-TB Gold Plus test
Chest X-ray, referral to the tuberculosis control center or specialist consultation, final diagnosis of latent tuberculosis infection and initiation of preventive treatment.
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