Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorClaudia Angeli

About this trial

The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury. The overall objective of this study is to demonstrate that epidural stimulation may be a method for improving stepping, standing and bladder function in individuals with spinal cord injury. With the use of epidural stimulation, the investigators propose to investigate how well the participant can stand and walk and how well the participant's bladder can store or hold urine as well as void or empty urine. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries that are unable to stand or walk and have impaired bladder function.

Eligibility criteria

Qualifiers

At least 18 years of age

non-progressive SCI

stable medical condition

Inability to stand and step independently

Disqualifiers

ventilator dependent

untreated painful musculoskeletal dysfunction, fracture or pressure sore

untreated psychiatric disorder or ongoing drug abuse

cardiovascular, respiratory, bladder, or renal disease unrelated to SCI

Trial design

Treatments tested in this trial

  • Epidural stimulation + Stand Training
  • Epidural stimulation + Step Training
  • Epidural stimulation + Bladder Capacity Training
  • Epidural stimulation + Bladder Voiding Efficiency Training

Treatment groups

16 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Claudia Angeli

Lead sponsor

Kessler Foundation

Sponsor institution

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator