[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100427873":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":22,"locations":28,"responsibleParty":47,"collaborators":50,"id":53,"slug":10,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Individuals with Tourette syndrome (TS)",null,"Individuals previously diagnosed with Tourette syndrome (TS). Participants must be 18 years of age or older.",[13],"Other: None - observational study",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"None - observational study",[9],[19],{"name":20,"affiliation":5,"role":21},"David A Isaacs, MD, MPH","PRINCIPAL_INVESTIGATOR",[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Michelle Eckland, BS","CONTACT","615-875-7394","michelle.r.eckland.1@vumc.org",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Nashville","Tennessee","37232-5400","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-86.78444,36.16589,{"lat":40,"lon":39},[43,45],{"name":24,"role":25,"phone":44,"phoneExt":10,"email":27},"6159362025",{"name":46,"role":21,"phone":10,"phoneExt":10,"email":10},"David Isaacs, MD, MPH",{"type":21,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"David Isaacs","Assistant Professor, Neuro-Movement Disorders Division",[51],{"name":52,"class":6},"University of California, Los Angeles","100427873",false,"NCT04851678","Longitudinal Impact of Stressors in Adults With Tourette Syndrome","LISA-TS","Inclusion Criteria:\n\n* adults (\\>18) meeting Diagnostic and Statistics Manual, 5th edition (DSM-V) criteria for Tourette syndrome, chronic motor tic disorder, or chronic vocal tic disorder\n* ability to provide informed consent\n* English proficiency\n\nExclusion Criteria:\n\n\\- significant medical, neurologic, or psychiatric diagnoses (e.g. uncontrolled epilepsy, chronic heart failure, schizophrenia) besides TS and its commonly co-occurring psychiatric diagnoses","ALL","18 Years",{"count":62,"type":63},140,"ESTIMATED","OBSERVATIONAL","The Investigators propose a two-year, longitudinal pilot study of TS adults (\\>18) to determine impact of lifetime environmental stress exposure on tic severity, psychiatric comorbidity severity, and health-related quality of life (HRQOL).",[67],"Tourette Syndrome",[69,70,71],"Stress","Environmental stress","Psychosocial stress","2026-04-28",{"date":74,"type":75},"2026-05-05","ACTUAL",{"date":77,"type":75},"2021-09-30",{"date":79,"type":63},"2027-06-30",{"name":5,"class":6},1]