[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622101":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":46,"collaborators":10,"id":48,"slug":10,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Mechanically ventilated patients with hypoxemia requiring clinical PEEP optimization",null,"The study will enroll mechanically ventilated patients under sedation\u002Fanalgesia without spontaneous breathing, exhibiting a oxygenation index (PaO₂\u002FFiO₂ ratio) \\\u003C300 mmHg, and deemed clinically eligible for PEEP titration by attending physicians.",[13],"Diagnostic Test: The lung recruitment potential assessed and PEEP titration by ventilator and 2D\u002F3D EIT",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","The lung recruitment potential assessed and PEEP titration by ventilator and 2D\u002F3D EIT","The patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R\u002FI ratio), with concurrent monitoring by both 2D- and 3D- EIT.",[9],[21],{"name":22,"affiliation":5,"role":23},"Huaiwu He","STUDY_CHAIR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","010-6915-2300","tjmuhhw@126.com",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences","RECRUITING","Beijing","Beijing Municipality","100730","China","CN",{"type":39,"coordinates":40},"Point",[41,42],116.39723,39.9075,{"lat":42,"lon":41},[45],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100622101",false,"NCT07379242","Lung Recruitment Assessed by 2D\u002F3D-EIT and R\u002FI Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Lung Recruitment Assessed by Two-Dimensional\u002FThree-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Inclusion Criteria:\n\n* Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.\n* Oxygenation index \\\u003C 300 mmHg.\n* Patients who are clinically judged by the attending doctor to require the PEEP titration.\n\nExclusion Criteria:\n\n* Aged under 18 years.\n* Pregnancy.\n* Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).\n* No informed consent obtained.\n* Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.\n* High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.","ALL","18 Years",{"count":57,"type":58},50,"ESTIMATED","OBSERVATIONAL","The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R\u002FI ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is:\n\nAre the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R\u002FI ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R\u002FI ratios measured at high and low PEEP levels.",[62],"Acute Respiratory Failure (ARF)",[64,65,66,67,68,69],"Acute respiratory failure","PEEP titration","3D-EIT","2D-EIT","Lung recruitability","R\u002FI ratio","2026-01-23",{"date":72,"type":73},"2026-01-30","ACTUAL",{"date":75,"type":73},"2025-09-01",{"date":77,"type":58},"2026-09-30",{"name":5,"class":6},1]