Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality. Prone position ventilation (PPV) is an evidence-based therapy that improves oxygenation and survival in patients with moderate to severe ARDS; however, outcomes remain heterogeneous. Early identification of patients at high risk of mortality after PPV may improve clinical decision-making and individualized management.
This retrospective observational study aims to develop and validate a machine learning model to predict intensive care unit (ICU) mortality in ARDS patients receiving prone position ventilation. Clinical, laboratory, and treatment variables collected from ICU electronic medical records will be used to construct prediction models using multiple machine learning algorithms. The performance of these models will be evaluated and compared to identify the optimal model for mortality prediction.
Diagnosis of ARDS according to the Berlin definition [15];
Receipt of at least one session of prone position ventilation (PPV) during hospitalization;
Requirement for mechanical ventilation.
Age <18 years;
PPV duration <6 hours;
ICU length of stay <24 hours;
Pregnancy;
Adult patients diagnosed with acute respiratory distress syndrome (ARDS) who received prone position ventilation in the intensive care unit at Zhongshan Hospital, Fudan University. Clinical data were collected retrospectively from electronic medical records.
Cohort
Retrospective
Prone Position Ventilation
Other interventionProne position ventilation applied as part of routine clinical care for patients with acute respiratory distress syndrome. No experimental intervention was assigned in this observational study.
ICU Mortality
Death from any cause during the intensive care unit (ICU) stay among patients with acute respiratory distress syndrome receiving prone position ventilation.
ARDS subphenotype classification based on machine learning model.
Number of patients classified into different ARDS subphenotypes using a machine learning model based on clinical and physiological variables collected at baseline.
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