Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age14-18
SponsorUniversity of Oregon

About this trial

This research will use biobehavioral approaches to generate understanding about the linkages between sleep duration and timing, stressful life events, and depressive symptoms in adolescents, with a long-term aim of developing effective preventative interventions.

Eligibility criteria

Qualifiers

14-18 years of age

Currently in high school

short and late sleep (weekday sleep duration ≤ 7 h and bedtime ≥ 22:30 (10:30 pm); n=100) or long and early sleep (weekday sleep duration > 7 hours and bedtime ≤ 22:30 (10:30 pm); n=50), indexed by the Munich Chronotype Questionnaire

Lifetime stressful event frequency ≥ 2 on the Stress and Adversity Inventory (STRAIN) Screener

Disqualifiers

Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for current moderate to severe alcohol/substance use disorder (≥4 symptoms);

Current clinician-provided diagnosis of narcolepsy or idiopathic hypersomnia;

Lifetime diagnosis of bipolar or schizophrenia spectrum disorder;

Certain medical conditions (e.g., serious neurological disorder, heart failure or serious heart trouble, history of head injury with unconsciousness > 5 minutes);

Trial design

Treatments tested in this trial

  • Sleep extension and advance
  • Regular sleep duration and timing

Treatment groups

150 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of Oregon

Lead sponsor

Oregon Research Institute

Collaborator

University of Pittsburgh

Collaborator

National Institute of Mental Health (NIMH)

Collaborator