Mechanisms of Rumination Change in Adolescent Depression
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age14-17
SponsorOhio State University
About this trial
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.
Eligibility criteria
Qualifiers
Previous diagnosis of Major Depressive Disorder (full or partial remission for at least two weeks) according to Diagnostic and Statistical Manual (DSM-V) criteria confirmed by the Kiddie Schedule for affective disorders (KSADSPL). Partial remission is defined as not meeting full DSM-V criteria for MDD.
RRS score above the age and sex specific mean, T > 50).
14-17 years of age at enrollment (accounting for 2 year follow-up),
Postpubertal (Petersen Pubertal Developmental Scale)
Disqualifiers
Endorsement of suicidality with plan or intent (assessed via KSADSPL and Children's Depression Rating Scale (CDRS-R) clinical interviews. Current or past (within previous three months) plan or intent is exclusionary.
Lifetime history of conduct disorder, autism, any psychotic disorder (or episode unexplained by other known medical causes), or bipolar disorder. Eating disorder or alcohol/substance abuse within the previous 6 months. (Lifetime history of an anxiety disorder, disruptive mood dysregulation disorder or oppositional defiant disorder, Attention Deficit Hyperactivity Disorder (ADHD) will not be exclusionary).
Current treatment with RF-CBT, Cognitive Behavioral Therapy (CBT), or variants thereof, or in the last 2 years. Likewise, detail oriented therapy beyond supportive therapy (e.g., homework, cognitive restructuring), in same time window (ability to recall elements of structured therapies with CBT focus).
Metal braces or retainers, tattoos with metal, or clothing with metal fibers.
Trial design
Treatments tested in this trial
- Rumination-Focused CBT
- Relaxation-based Therapy
Treatment groups
183 Participants
are divided into 3 treatment groupsSponsors and collaborators
Ohio State University
Lead sponsor
University of Exeter
Collaborator
National Institute of Mental Health (NIMH)
Collaborator
University of Utah
Collaborator
Nationwide Children's Hospital
Collaborator
Utah Center for Evidence Based Treatment
Collaborator
Source ClinicalTrials.gov