[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100501284":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":32,"responsibleParty":50,"collaborators":10,"id":53,"slug":10,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"pregnant patients with systemic rheumatological diseases",null,"pregnant patients with systemic rheumatological diseases undergoing assisted fertilization techniques",[13],"Other: collection and analysis of treatments and procedures already performed by normal clinical practice",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"collection and analysis of treatments and procedures already performed by normal clinical practice","The patients' anthropometric variables; laboratory test results; PMA techniques (types of fertilization\u002Fdrugs used for stimulation) and the outcome of the eventual pregnancy (ongoing treatment during the pregnancy itself, development of maternal\u002Ffetal complications, such as hypertension, preeclmpsia, thrombotic events, renal failure, disease flare, neonatal outcome) and data on the type of ovarian stimulation drug treatment.",[9],[20],{"name":21,"affiliation":22,"role":23},"Patrizia Rovere Querini, PhD, MD","IRCCS Ospedale San Raffaele","PRINCIPAL_INVESTIGATOR",[25,29],{"name":21,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","+390226436095","rovere.patrizia@hsr.it",{"name":30,"role":26,"phone":27,"phoneExt":10,"email":31},"Valentina Canti, MD","canti.valentina@hsr.it",[33],{"facility":34,"status":35,"city":36,"state":10,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"San Raffaele Hospital","RECRUITING","Milan","Italy","IT",{"type":40,"coordinates":41},"Point",[42,43],9.18951,45.46427,{"lat":43,"lon":42},[46,49],{"name":47,"role":26,"phone":48,"phoneExt":10,"email":28},"Patrizia Rovere Querini, PhD,MD","+390226433065",{"name":30,"role":26,"phone":27,"phoneExt":10,"email":31},{"type":23,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Rovere Querini Patrizia","Associate Professor of Internal Medicine, Vita-Salute San Raffaele University Head physician, U.O. General Medicine and Continuity of Care, IRCCS San Raffaele Hospital","100501284",false,"NCT05807256","Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases","Assessment of Maternal-fetal Outcome in Pregnancy From Medically Assisted Fertilization Techniques in Women With Systemic Immunoreumatologic Diseases","Inclusion Criteria:\n\n* Patients diagnosed with systemic immunoreumatologic disease such as SLE, APS, RA, SpA, SclS, SS, PM-DM, vasculitis\n* patients who have performed one or more PMAs between January 2000 and April 2021\n* patients who had their last follow-up by February 2022\n\nExclusion Criteria:\n\n* Patients diagnosed with only one organ autoimmunity (e.g., diabetes mellitus I, thyroiditis of Hashimoto's, celiac disease or chronic inflammatory bowel disease in the absence of systemic disease associated);\n* patients with severe renal failure, significant pulmonary hypertension or cardiomyopathy severe.","FEMALE","18 Years","50 Years",{"count":63,"type":64},500,"ESTIMATED","OBSERVATIONAL","Systemic rheumatological diseases often occur in young women of childbearing age and can therefore impact fertility. There are diseases, such as arthritis, which present no contraindication to assisted reproductive techniques (ARTs), because there is no influence on the disease itself if the disease activity at conception is stable. On the other hand, patients suffering from connective tissue diseases, primarily Systemic Lupus Erythematosus (SLE) and patients suffering from primary or SLE-related Anti-Phospholipid Antibody Syndrome (APS), deserve more targeted therapies both in the context of ARTs and in the ensuing pregnancy.\n\nTo evaluate the response to ARTs in patients with systemic rheumatological diseases, both in terms of reactivation of the underlying pathology and in terms of ARTs outcome.",[68,69,70,71,72],"Rheumatic Diseases","Fertility Disorders","Pregnancy, High Risk","Pregnancy Complications","Immunologic Disease","2025-06-17",{"date":75,"type":76},"2025-06-18","ACTUAL",{"date":78,"type":76},"2022-05-04",{"date":80,"type":64},"2025-11-30",{"name":5,"class":6},1]