Medication Understanding in MS
ConditionMultiple Sclerosis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Nottingham
About this trial
The goal of this observational study is to learn how people with multiple sclerosis (MS) understand, organise, and use their medicines at home. The study aims to explore how people take their prescribed and non-prescribed medicines, what challenges they experience, and whether any safety issues arise in day-to-day medication use.
Participants will take part in one home visit with trained student researchers. During the visit, researchers will review all medicines and supplements the participant uses, ask about routines and any difficulties, check medication packaging with permission, and ask a brief question about memory. No treatment changes will be made. Information will be reviewed by a senior clinician, and any safety concerns will be shared with the participant's usual healthcare team.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adults aged 18 years and over with a confirmed diagnosis of multiple sclerosis
Living in the community (not in residential care)
Taking at least one prescribed medication
Able to provide informed consent or, for those without capacity to provide informed consent, with a consultee available to provide consultee declaration and provide information during home-based medication review
Disqualifiers
Severe cognitive or communication impairment without a consultee to provide consultee declaration and medication-related information
Participants for whom a home visit is deemed unsafe
Non-English speakers
Trial population
From outpatient neurology (Nottingham) and rehabilitation medicine (Derby) settings
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
80 Participants
are grouped into 1 trial groupGroup A: People with multiple sclerosis
Trial outcomes
Primary outcomes
1
Medication Burden (Descriptive)
Total number of prescribed and non-prescribed medications and supplements used by each participant, recorded during the home-based medication review. This includes dose, frequency, route, and source of each item. The outcome will be summarised descriptively (counts, means, ranges).
Time frame
BaselineSecondary outcomes
1
Medication Adherence (MARS-5 Score)
Self-reported adherence measured using the 5-item Medication Adherence Report Scale (MARS-5). Scores range from 5 to 25, with higher scores indicating better adherence. Results will be summarised descriptively.
Time frame
Baseline2
Medication-Related Challenges
Proportion of participants reporting difficulties with medication supply, administration, formulation, or perceived effectiveness, based on structured trigger questions. Reported descriptively.
Time frame
Baseline3
Subjective Cognitive Decline (Single-Item Question)
("Yes"/"No") to the validated single-item subjective cognitive decline question ("Do you feel you have more problems with your memory than most?"). Used to contextualise medication-taking behaviours. Summarised descriptively.
Time frame
Baseline4
Medication Organisation and Use of Aids
Use of medication aids such as dosette boxes, blister packs, phone reminders, or charts. Recorded as present/absent and described using frequencies.
Time frame
BaselineLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Nottingham
Lead sponsor
University Hospitals of Derby and Burton NHS Foundation Trust
Collaborator
Nottingham University Hospitals NHS Trust
Collaborator
Source ClinicalTrials.gov
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