The equilibrium of intestinal microorganisms is essential for health an imbalance has been associated with an increased risk in the development of different pathologies; including colorectal cancer.
Rectal cancer is the third most common neoplasm worldwide and the complete excision of the mesorectum is a major prognostic factor.
The identification of microorganisms in the adipose tissue that surrounds the small intestine in inflammatory diseases, together with bacterial alterations found in colonic mucosa and feces in patients with rectal cancer in comparison with healthy individuals indicates that microbiome alteration plays an essential role in pathogenesis.
The mesorectal microbiome in rectal cancer patients stills unknown and given its importance in the prognostic of the disease the goal of this study is to identify microbial profiles that allow predicting rectal cancer patients with a poor prognosis.
Patients with colorectal cancer that will undergo elective surgery
Patients diagnosed with non-oncological disease with an indication for elective surgery.
Age ≥ 18 years
Histology proven adenocarcinoma or adenoma with or without chemotherapy or neoadjuvant radiochemotherapy
Colorectal tumor with different histology to adenocarcinoma or adenoma
History of colorectal cancer surgery different to the local excision
Patients with psychiatric illness, addiction or disorder with inability to understand informed consent
Inability to read or understand any of the languages of the informed consent and questionnaires (Catalan, spanish)
University Hospital of Girona Dr. Josep Trueta
Lead sponsor
Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Sponsor institution
Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Collaborator