Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversity of Copenhagen
About this trial
The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively.
The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.
Eligibility criteria
Qualifiers
Male or female.
Age between 18-40 years old
BMI between 18.5-29
Disqualifiers
Diabetes
Kidney- or liver disease
Pregnant, lactating or planning to become pregnant within the study period
Supplementation with SCFAs
Trial design
Treatments tested in this trial
- Propionate followed by Butyrate
- Butyrate followed by Propionate
- Propionate followed by Butyrate
- Butyrate followed by Propionate
Treatment groups
10 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov