[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486701":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":26,"locations":35,"responsibleParty":71,"collaborators":74,"id":78,"slug":25,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":25,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Columbia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"15-Minute mbNF","ACTIVE_COMPARATOR","Participants receiving mindfulness training and 15-minute session of mbNF",[13],"Other: Mindfulness + fMRI Neurofeedback",{"label":15,"type":10,"description":16,"interventionNames":17},"30-Minute mbNF","Participants receiving mindfulness training and 30-minute session of mbNF",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Mindfulness + fMRI Neurofeedback","Prior to neurofeedback, participants will receive 45 minutes of mindfulness training. Participants will then receive mindfulness-based fMRI neurofeedback targeting the default mode network and frontoparietal control network.",[9,15],[24],"Mindfulness-based Real-time fMRI Neurofeedback",null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Randy P Auerbach, PhD","CONTACT","646-774-5745","rpa2009@cumc.columbia.edu",{"name":33,"role":29,"phone":25,"phoneExt":25,"email":34},"Simryn Molina, BA","simryn.molina@nyspi.columbia.edu",[36,56],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Northeastern University","RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-71.05977,42.35843,{"lat":48,"lon":47},[51,54],{"name":52,"role":29,"phone":25,"phoneExt":25,"email":53},"Susan Whitfield-Gabrieli, PhD","s.whitfield-gabrieli@northeastern.edu",{"name":52,"role":55,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"facility":57,"status":38,"city":58,"state":58,"zip":59,"country":42,"countryCode":43,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Columbia University Irving Medical Center","New York","10032",{"type":45,"coordinates":61},[62,63],-74.00597,40.71427,{"lat":63,"lon":62},[66,67,69],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},{"name":68,"role":29,"phone":25,"phoneExt":25,"email":25},"Randy P Auerbach",{"name":70,"role":55,"phone":25,"phoneExt":25,"email":25},"Randy Auerbach, PhD",{"type":55,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Randy P. Auerbach, Ph.D., ABPP","Professor",[75],{"name":76,"class":77},"National Institute of Mental Health (NIMH)","NIH","100486701",false,"NCT05617495","Mindfulness-Based fMRI Neurofeedback for Depression","Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)","mbNF","Inclusion Criteria:\n\n* Ages 13-18 years-old\n* Written informed assent\u002Fconsent and parental\u002Fguardian permission for 13-17 year-olds or informed consent for 18 year-olds\n* Tanner puberty stage ≥3\n* Meets current diagnostic criteria for MDD\n* English fluency\n\nExclusion Criteria:\n\n* Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders\n* Substance use disorder, moderate or severe in past 6 months\n* Active suicidal ideation with a specific plan\n* History of seizure disorder\n* Medical or neurological illness (e.g., severe head injury)\n* MRI contraindications\n* Current psychotropic medication use other than antidepressant medication\n* Intelligence quotient (IQ) \\\u003C80.","ALL","13 Years","18 Years",{"count":89,"type":90},90,"ESTIMATED","INTERVENTIONAL",[93],"NA","In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.",[96,97],"Depression in Adolescence","Rumination",[99,100,97,101],"Real-time fMRI Neurofeedback","Mindfulness","Major Depressive Disorder","2026-04-24",{"date":104,"type":105},"2026-04-29","ACTUAL",{"date":107,"type":105},"2024-04-10",{"date":109,"type":90},"2027-06-30",{"name":5,"class":6},2]