Mode of Exercise and Bone Biomarkers in Older Veterans

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorVA Office of Research and Development

About this trial

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.

Eligibility criteria

Qualifiers

Healthy older (60+ y) Veteran women and men in the Denver Metro Area

Normally active (e.g., recreational cycling or walking exercise)

Disqualifiers

Impaired renal function, defined as an eGRF of <60 mL/min/1.73m2

Hepatobiliary disease, defined as liver function tests (AST, ALT) >1.5 times the upper limit of normal

Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) <0.5 or >5.0 mU/L

Serum Ca <8.5 or >10.3 mg/dL

Trial design

Treatments tested in this trial

  • 10 Weeks of Supervised Resistance Exercise Training
  • 10 Weeks of Supervised Endurance Exercise Training

Treatment groups

120 Participants
are divided into 2 treatment groups

Sponsors and collaborators

VA Office of Research and Development

Lead sponsor

University of Colorado, Denver

Collaborator