[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100329485":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":27,"locations":32,"responsibleParty":48,"collaborators":10,"id":50,"slug":10,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"University of Ljubljana","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients undergoing surgery",null,"Patients subject to TIVA",[13],"Drug: Propofol",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DRUG","Propofol","Patients undergoing surgery, TIVA (total intravenous anaesthesia)",[9],[21,24],{"name":22,"affiliation":5,"role":23},"Gorazd Karer","PRINCIPAL_INVESTIGATOR",{"name":25,"affiliation":26,"role":23},"Iztok Potočnik","University Medical Centre Ljubljana",[28],{"name":22,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","+386 1 4768701","gorazd.karer@fe.uni-lj.si",[33],{"facility":26,"status":34,"city":35,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Ljubljana","1000","Slovenia","SI",{"type":40,"coordinates":41},"Point",[42,43],14.50513,46.05108,{"lat":43,"lon":42},[46],{"name":25,"role":29,"phone":10,"phoneExt":10,"email":47},"iztok.potocnik@kclj.si",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100329485",false,"NCT03569839","Modeling and Closed-loop Control of Depth of Anaesthesia","Inclusion Criteria:\n\n* patients having vitroretinal surgery in general anaesthesia\n* patients having brain surgery in general anaesthesia\n* patients needing sedation in ICU\n* ASA 1-3\n\nExclusion Criteria:\n\n* ASA \\> 3\n* BMI \\> 35\n* drug addicts\n* patients taking psychotropic medicines\n* patients taking opioid analgesics (including tramadol)\n* severe psychiatric disease\n* central nervous system disease (except the reason for surgery)\n* arrhythmia affecting or preventing the measurements (e.g. chronic atrial fibrillation)\n* patients that received benzodiazepines",true,"ALL","20 Years","70 Years",{"count":60,"type":61},50,"ESTIMATED","OBSERVATIONAL","The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing algorithms for better and safer administration of anaesthetic agents.",[65],"The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation","2026-05-05",{"date":68,"type":69},"2026-05-11","ACTUAL",{"date":71,"type":69},"2017-09-14",{"date":73,"type":61},"2028-12",{"name":5,"class":6},1]