[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100407625":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":18,"centralContacts":19,"locations":29,"responsibleParty":110,"collaborators":18,"id":112,"slug":18,"hasResults":113,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":18,"eligibilityCriteria":117,"healthyVolunteers":113,"sex":118,"minAge":119,"maxAge":18,"enrollmentInfo":120,"targetDuration":18,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":18,"overallStatus":32,"whyStopped":18,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":138},{"fullName":5,"class":6},"Gruppo Italiano Malattie EMatologiche dell'Adulto","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Biological evaluation","evaluation of molecular changes in CD34+ blast cells at the time of relapse after allo-HSCT.",[12],"Other: bone marrow withdrawal",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"bone marrow withdrawal","bone marrow samples evaluation",[9],null,[20,25],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},"Paola Fazi","CONTACT","0670390528","p.fazi@gimema.it",{"name":26,"role":22,"phone":27,"phoneExt":18,"email":28},"Enrico Crea","0670390514","e.crea@gimema.it",[30,46,57,68,79,90,98],{"facility":31,"status":32,"city":33,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Aou Consorziale Policlinico - Bari - Uo Ematologia Con Trapianto","RECRUITING","Bari","Italy","IT",{"type":37,"coordinates":38},"Point",[39,40],16.86982,41.12066,{"lat":40,"lon":39},[43],{"name":44,"role":22,"phone":18,"phoneExt":18,"email":45},"Pellegrino Musto","pellegrino.musto@uniba.it",{"facility":47,"status":32,"city":48,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"Unità di Ricerca e di Malattie del sangue - Ematologia S. Luca Vecchio","Florence",{"type":37,"coordinates":50},[51,52],11.24626,43.77925,{"lat":52,"lon":51},[55],{"name":56,"role":22,"phone":18,"phoneExt":18,"email":18},"Valeria Santini",{"facility":58,"status":32,"city":59,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"AOU San Martino-IST-Ematologia 1","Genova",{"type":37,"coordinates":61},[62,63],11.87211,45.21604,{"lat":63,"lon":62},[66],{"name":67,"role":22,"phone":18,"phoneExt":18,"email":18},"Carmela Di Grazia",{"facility":69,"status":32,"city":70,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Sezione di Ematologia - Ospedale S.Maria della Misericordia","Perugia",{"type":37,"coordinates":72},[73,74],12.38878,43.1122,{"lat":74,"lon":73},[77],{"name":78,"role":22,"phone":18,"phoneExt":18,"email":18},"Cristina Mecucci",{"facility":80,"status":32,"city":81,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Dip. di Medicina Trasl. E di Precisione - U.O.C. Ematologia","Roma",{"type":37,"coordinates":83},[84,85],11.10642,44.99364,{"lat":85,"lon":84},[88],{"name":89,"role":22,"phone":18,"phoneExt":18,"email":18},"Massimo Breccia",{"facility":91,"status":32,"city":81,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":92,"geoPoint":94,"contacts":95},"Policlinico Tor Vergata",{"type":37,"coordinates":93},[84,85],{"lat":85,"lon":84},[96],{"name":97,"role":22,"phone":18,"phoneExt":18,"email":18},"Maria Teresa Voso",{"facility":99,"status":32,"city":100,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Ististuto Clinico Humanitas - Rozzano - Uo Oncologia Medica Ed Ematologia","Rozzano",{"type":37,"coordinates":102},[103,104],9.1559,45.38193,{"lat":104,"lon":103},[107],{"name":108,"role":22,"phone":18,"phoneExt":18,"email":109},"Matteo E Della Porta","matteo.della_porta@hunimed.eu",{"type":111,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100407625",false,"NCT04587856","Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in MDS Patients","Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in Patients With Myelodysplastic Syndrome","Inclusion Criteria:\n\n* Diagnosis of MDS according to 2016 WHO criteria\n* Aged 18y or older\n* Patients who will receive allogeneic stem cell transplantation (HSCT)\n* Signed written informed consent according to ICH\u002FEU\u002FGCP and national local laws\n\nExclusion Criteria:\n\n* Second HSCT procedure.","ALL","18 Years",{"count":121,"type":122},38,"ESTIMATED","INTERVENTIONAL",[125],"NA","This is a biological study for adult MDS patients who undergo HSCT procedure. Viable bone marrow samples will be collected and cryopreserved from MDS patients before transplantation and at clinical disease recurrence. CD34+ blast cells at disease relapse after HSCT will be compared with CD34+ cells collected before transplant to study genomic and transcriptomic changes.",[128],"Myelodysplastic Syndromes","2024-10-21",{"date":131,"type":132},"2024-10-22","ACTUAL",{"date":134,"type":132},"2021-02-12",{"date":136,"type":122},"2025-03",{"name":5,"class":6},7]