[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575959":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":60,"collaborators":10,"id":62,"slug":10,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":74,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Shengjing Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Retrospective cohort of patients confirmed diagnosed with chronic hepatitis B",null,"Patients aged ≥ 18 who have been diagnosed with chronic hepatitis B from Jan 2010 to Oct 2024",[13,14],"Device: MRE","Device: Liver biopsy",{"label":16,"type":10,"description":17,"interventionNames":18},"Prospective follow-up cohort of patients confirmed diagnosed with chronic hepatitis B","Patients aged ≥ 18 who have been diagnosed with chronic hepatitis B, both treated and untreated from Aug 2022",[13,14],[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DEVICE","MRE","All imaging studies were performed by using a 1.5T\u002F3.0-T MRI system",[16,9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Liver biopsy","Liver biopsy are performed by well-trained pathologists in accordance with standard operating procedures.",[16,9],[30],{"name":31,"affiliation":5,"role":32},"Yu Shi","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Yiyang Wang","CONTACT","+86 15291014907","15291014907@163.com",{"name":31,"role":36,"phone":40,"phoneExt":10,"email":41},"+86 189 4025 9980","18940259980@163.com",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Shenyang","Liaoning","210000","China","CN",{"type":51,"coordinates":52},"Point",[53,54],123.43278,41.79222,{"lat":54,"lon":53},[57,58],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},{"name":31,"role":36,"phone":59,"phoneExt":10,"email":41},"+86 18940259980",{"type":32,"investigatorFullName":31,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Deputy director of department of radology","100575959",false,"NCT06779058","MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B","Retrospective and Prospective Multi-center Clinical Study of Magnetic Resonance Elastography in Evaluating Hepatic Fibrosis in Chronic Viral Hepatitis B","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Confirmed CHB (laboratory, imaging and clinical tests)\n* MRE within 6 months before and after liver biopsy\n* Treatment-naïve\n* Child-Pugh Grade A (\\\u003C7 points)\n* Written informed consent in prospective follow-up cohort\n\nExclusion Criteria:\n\n* Patients with liver malignant tumor\n* Chronic hepatitis due to other causes (such as alcoholic hepatitis)\n* CHB combined with hepatitis C, hepatitis D, or HIV\n* Patients with biliary tract diseases\n* Contraindications of MRE examination, MRE failure\n* Poor pathological effect","ALL","18 Years","80 Years",{"count":72,"type":73},600,"ESTIMATED","2 Years","OBSERVATIONAL","How to construct a non-invasive, accurate, and convenient method to evaluate the severity of liver fibrosis (LF) is an important general problem in the management of patients with chronic hepatitis B (CHB). We plan to investigate the ability of magnetic resonance elastography (MRE) to grade fibrosis in chronic hepatitis B and apply to clinical longitudinal follow-up.",[78,79],"Chronic Hepatitis B","Liver Fibrosis",[81,82,83],"Magnetic resonance elastography","Liver stiffness","Antiviral therapy","2026-02-26",{"date":86,"type":87},"2026-02-27","ACTUAL",{"date":89,"type":87},"2025-01-01",{"date":91,"type":73},"2026-12-01",{"name":5,"class":6},1]