[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100241458":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":19,"centralContacts":24,"locations":33,"responsibleParty":51,"collaborators":10,"id":53,"slug":10,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8,11,13,15,17],{"label":9,"type":10,"description":10,"interventionNames":10},"Normal Healthy Volunteer",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Non-CKD Control",{"label":14,"type":10,"description":10,"interventionNames":10},"Chronic Kidney Disease (CKD)",{"label":16,"type":10,"description":10,"interventionNames":10},"Dialysis Patients",{"label":18,"type":10,"description":10,"interventionNames":10},"Renal Transplant Recipients",[20],{"name":21,"affiliation":22,"role":23},"Xiufeng Li, Ph.D.","Univesity of Minnesota","PRINCIPAL_INVESTIGATOR",[25,29],{"name":21,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","612-625-7872","lixx1607@umn.edu",{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},"Michelle Hartwig","612-626-0021","mhartwig@umn.edu",[34],{"facility":35,"status":10,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Center for Magnetic Resonance Research","Minneapolis","Minnesota","55455","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-93.26384,44.97997,{"lat":45,"lon":44},[48,50],{"name":21,"role":26,"phone":49,"phoneExt":10,"email":10},"612-626-2001",{"name":21,"role":23,"phone":10,"phoneExt":10,"email":10},{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100241458",false,"NCT02421497","MRI Technical Development and Applications in Kidney Disease","For Specific Aim 1: MRI Technical Development Studies\n\nInclusion Criteria:\n\n1\\. Healthy Volunteer\n\nExclusion Criteria:\n\n1. Ferromagnetic implants\n2. Any foreign metal objects in the body\n3. History of shrapnel or shot gun injury\n4. Cardiac pacemakers\n5. Defibrillator\n6. Neuronal stimulator\n7. Magnetic aneurysm clip\n8. Large tattoos on the abdomen or the brain and neck\n9. Hip replacement\n10. Too large to fit in the magnet (body mass index \\>= 40, approx.)\n11. Severe claustrophobia\n12. Women with pregnancy\n\nFor Specific Aim 2: Pilot Studies with Patients\n\nStudies for CKD\n\nInclusion\n\n1. English- speaking as primary language.\n2. Age 45 years and older\n3. Able to complete an approximately 90 minute cognitive testing battery.\n4. Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.\n5. GFR \\\u003C 90 ml\u002Fmin\u002F1.73m2\n\nExclusion\n\n1. Acute psychiatric illness that would impede cognitive testing\n2. Active chemical dependence, such as alcohol, narcotics or other drugs\n3. Legally blind or unable to complete cognitive tests due to visual loss or deafness\n4. Dialysis dependent or renal transplant recipient at time of screening or baseline\n5. Chronic obstructive pulmonary disease\n6. Severe CI unable to complete the Modified Mini-Mental State Examination \\[3MSE\\]\n\nStudies for Renal Transplantation\n\nInclusion\n\n1. Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.\n2. Age 45 years and older\n\nExclusion\n\n1. Not on dialysis due to allograft failure\n2. Chronic obstructive pulmonary disease",true,"ALL","18 Years","70 Years",{"count":63,"type":64},180,"ESTIMATED","OBSERVATIONAL","Magnetic resonance imaging (MRI), as a non-invasive and non-contrast enhanced technique, has the potential to improve patient health care and management. The overall objective of proposed project is to:\n\n1. develop, customize, and optimize anatomic and functional MRI methods,\n2. explore the use of MRI methods to study CKD and evaluate post-transplant kidneys, and\n3. investigate the potential of MRI in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction.\n\nIn addition to direct studies of the kidney, brain MRI studies will also be performed to identify the cerebrovascular and cognitive effects of chronic renal function deficiency and medical treatment (e.g. hemodialysis and immunosuppression). The brain and kidneys have similar vascular bed, and both are susceptible to vascular injury, which provides the pathological basis for the widely recognized association of reduced renal function with prevalent cerebrovascular diseases (CVDs) and cognitive impairment (CI). The MRI methods in the brain will be applied to explore the origins for widely observed CVDs and prevalent cognitive impairment (CI) in kidney disease patients.",[68,69,70,71],"Chronic Kidney Diseases","Kidney Transplantation","Dialysis","Cognition Disorders","NOT_YET_RECRUITING","2026-04-09",{"date":75,"type":76},"2026-04-13","ACTUAL",{"date":78,"type":64},"2028-06-30",{"date":80,"type":64},"2029-12-30",{"name":5,"class":6},1]