[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637904":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":11,"locations":17,"responsibleParty":33,"collaborators":10,"id":37,"slug":10,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":10,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":55,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"Adults with OSA who developed central and\u002For mixed sleep apneas after MMA",null,[12],{"name":13,"role":14,"phone":15,"phoneExt":10,"email":16},"Dr. Ho","CONTACT","020-5663898","j.p.ho@amsterdamumc.nl",[18],{"facility":19,"status":10,"city":20,"state":21,"zip":22,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Department of Oral and Maxillofacial Surgery","Amsterdam","North Holland","1105 AZ","Netherlands","NL",{"type":26,"coordinates":27},"Point",[28,29],4.88969,52.37403,{"lat":29,"lon":28},[32],{"name":13,"role":14,"phone":15,"phoneExt":10,"email":16},{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Prof. dr. J. de Lange, MD DMD","Prof. dr.","100637904",false,"NCT07596719","Natural History of Central and Mixed Sleep Apneas Followed by Maxillomandibular Advancement for Obstructive Sleep Apnea","CMAI","Inclusion Criteria:\n\n* Adults aged 18 years or older;\n* Mild to severe OSA as determined by a polysomnography (PSG) preoperatively;\n* Completion of MMA for OSA treatment;\n* Subjects with preoperative and postoperative PSG;\n* Patients who are present with MMA treatment-related central apneas postoperatively\n\nExclusion Criteria:\n\n* Patients who underwent other adjunctive procedures at the time of MMA (e.g., multi-piece Le Fort osteotomy, TMJ reconstruction);\n* Previous history of orthognathic surgery;\n* Cleft palate and syndromic patients.","ALL","18 Years",{"count":46,"type":47},60,"ESTIMATED","OBSERVATIONAL","The goal of this observational prospective cohort study is to learn about the natural course of central and mixed sleep apneas that develop after maxillomandibular advancement (MMA) surgery for obstructive sleep apnea (OSA) in adult patients.\n\nThe main question it aims to answer is:\n\nDo central and mixed apneas resolve, partially resolve, or persist in the long term after MMA?\n\nParticipants will:\n\nUndergo a first postoperative polysomnography (PSG) at 3-6 months after MMA (part of standard care).\n\nBe invited into the study if central\u002Fmixed apneas are detected (CMAI% \\>25%). Undergo a second PSG at least 12 months after MMA (extra study procedure)",[51,52,53,54],"Sleep Apnea Syndrome (OSAS)","Central Sleep Apnea","Maxillomandibular Advancement Surgery","Orthognathic Surgical Procedures",[56,57,52],"OSA","MMA","NOT_YET_RECRUITING","2026-05-13",{"date":61,"type":62},"2026-05-19","ACTUAL",{"date":64,"type":47},"2026-12-01",{"date":66,"type":47},"2027-12-31",{"name":5,"class":6},1]