Navigate - Improving Survival and Quality of Life in Vulnerable Lung Cancer Patients

ConditionLung Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorZealand University Hospital

About this trial

Half of patients with lung cancer face a limited life span of one-year survival, which is characterized by severe physical and psychological symptoms. Differences in stage, comorbidity but also treatment may explain a large proportion of the social inequality in lung cancer survival. Some vulnerable patients may not receive first line treatment as planned either due to poor performance status or if they are not able to adhere to treatment appointments. Knowing how to navigate the health system may be a barrier preventing vulnerable patients in receiving optimal treatment. The primary aim of this randomised, controlled trial is to test whether a nurse-led individually tailored program including systematic screening of symptoms using PROs and a physical training program will significantly improve a composite outcome of survival and quality of life as the primary outcome among vulnerable lung cancer patients compared with standard care. Secondary outcomes include adherence to cancer treatment, symptom burden and overall survival.

Eligibility criteria

Qualifiers

Age ≥ 18 years of age

Diagnosed with NSCLC at all stages regardless of treatment intension at the participating departments

Performance status ≤ 2

Vulnerable according to pre-defined criteria

Disqualifiers

Severe untreated psychiatric disorder (e.g. psychosis) or cognitive problems (e.g. dementia) preventing informed consent

Not able to receive treatment

Not able to read and understand Danish -

Trial design

Treatments tested in this trial

  • NAVIGATE

Treatment groups

250 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Zealand University Hospital

Lead sponsor

Danish Cancer Society

Collaborator

Odense University Hospital

Collaborator

Vejle Hospital

Collaborator

Hospital of Southern Jutland

Collaborator