Neural Control of Kidney Blood Flow During Exercise in African American Adults

ConditionHealthy

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-35

SponsorUniversity of Massachusetts, Boston

About this trial

The goal of this clinical trials is to learn if healthy young African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are:

* Do healthy young AA adults have a larger decrease in kidney blood flow during exercise compared to W adults? * Do healthy young AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults?

During two visits in the research lab, participants will:

* Perform a fitness test * Perform cycling exercise while lying down * Undergo a cold hand test * Perform a mental math test

Completing this clinical trial will help researchers to understand more about why many AA adults have heart and kidney problems, so future research can study ways to reduce the number of AA adults who have these health issues.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Self-report as either African American or White racial identity

Born in United States

Both biological parents identify as same racial identity as participant

Recreationally active (participating in physical activity for at least 20 minutes per day, at least three times per week, but not training for competitive events)

Disqualifiers

Hispanic or Latino

Females who are pregnant or lactating

Cardiovascular or renal disease

Hypertension (blood pressure of more than or equal to 130/80 mmHg)

Trial design

Design model

Parallel

Treatments tested in this trial

Acute exercise
Other intervention
Participants will lie in a semi-supine position with their feet attached to the pedals of a custom-arranged cycle ergometer. Participants' 40% heart rate reserve will be calculated, giving the target value to achieve during exercise based on appropriate resistance applied on the cycle ergometer, corresponding to a moderate exercise intensity. After a 5-minute resting baseline, participants will perform dynamic cycling exercise at steady state for up to 20 minutes. They will then stop exercising, and there will be a 5-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived exertion will be taken from participants during the last 30 seconds of steady-state cycling exercise.
Cold pressor test
Other intervention
Participants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will have their hand immersed in ice water for 2 minutes. This cold pressor test represents the non-exercise, physical sympathetic stressor. Participants' hand will then be removed from the ice water, followed by a 3-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. Ratings of hand pain and cold perception will be taken from participants during the last 30 seconds of the cold pressor test.
Mental stress test
Other intervention
Participants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will perform a mental arithmetic task for 5 minutes. This mental stress test represents the non-exercise, psychological sympathetic stressor. Participants will be instructed to subtract a given number from a randomly selected three-digit number and verbally state their answer and continue to do so for the duration of the test. Participants will be instructed to state their answers as quickly and accurately as possible. Participants will then stop the arithmetic task, and a 3-minute recovery period will follow. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived stress will be taken from participants during the last 30 seconds of the mental stress test.

Treatment groups

32 Participants

are divided into 2 treatment groups

Group A: African American AdultsExperimental treatment 3 interventions

Group B: White AdultsExperimental treatment 3 interventions

Trial outcomes

Primary outcomes

Change in renal vascular resistance during acute exercise

For the acute exercise intervention, the percent change from pre-acute exercise to during steady-state exercise will be assessed.

Time frame

Pre-acute exercise and during steady-state exercise

Change in renal vascular resistance during cold pressor test

For the cold pressor test intervention, the percent change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.

Time frame

Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test

Change in renal vascular resistance during mental stress test

For the mental stress test intervention, the percent change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.

Time frame

Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test

Secondary outcomes

Change in renal blood flow velocity during acute exercise

For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.

Time frame

Pre-acute exercise and during steady-state exercise

Change in mean arterial blood pressure during acute exercise

For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.

Time frame

Pre-acute exercise and during steady-state exercise

Change in systolic blood pressure during acute exercise

For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.

Time frame

Pre-acute exercise and during steady-state exercise

Change in diastolic blood pressure during acute exercise

For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.

Time frame

Pre-acute exercise and during steady-state exercise

Other outcomes

Rating of perceived exertion during acute exercise

For the acute exercise intervention, the rating will be taken during the last 30 seconds of steady-state exercise. The Borg Scale of Perceived Exertion will be used, with which a rating from 6 to 20 will be taken, with 6 representing no exertion and 20 representing maximal exertion.

Time frame

During last 30 seconds of steady-state exercise

Rating of hand pain during cold pressor test

For the cold pressor test intervention, the rating will be taken during the last 30 seconds of the cold pressor test. A scale from 0 to 10 will be used to take the rating, with 0 representing no pain and 10 representing the worst possible pain.

Time frame

During last 30 seconds of cold pressor test

Rating of cold perception during cold pressor test

For the cold pressor test intervention, the rating will be taken during the last 30 seconds of the cold pressor test. A scale from 0 to -11 will be used to take the rating, with 0 representing no perceived cold and -11 representing unbearable cold.

Time frame

During last 30 seconds of cold pressor test

Rating of perceived stress during mental stress test

For the mental stress test intervention, the rating will be taken during the last 30 seconds of the mental stress test. A scale from 0 to 4 will be used to take the rating, with 0 representing no perceived stress and 4 representing extremely stressful.

Time frame

During last 30 seconds of mental stress test

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Massachusetts, Boston

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Source ClinicalTrials.gov

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