This multicenter interventional study in Ukraine is designed to compare the effectiveness of cryoablation and radiofrequency ablation in managing neuroma-associated pain following combat-related trauma. Adult patients with clinically significant neuropathic pain caused by neuromas will be randomly assigned to receive either image-guided cryoablation or radiofrequency ablation of the affected nerve. Cryoablation uses controlled cold temperatures to temporarily disrupt nerve conduction, while radiofrequency ablation uses thermal energy to modulate nerve function. Both interventions are minimally invasive and performed under image guidance. The study will evaluate changes in pain intensity, opioid consumption, functional outcomes, and patient-reported measures at predefined time points following the procedure. This research aims to provide evidence on which intervention is more effective in reducing pain, improving function, and minimizing the need for opioid medications in patients with combat-related neuroma pain.
Age 18 years or older
Sustained combat-related trauma
Clinically significant neuroma-associated pain localized to a peripheral nerve or neuroma
Moderate to severe pain (score ≥ 4 on a standardized numeric pain rating scale)
Age under 18 years
Pregnant or breastfeeding
Severe uncontrolled medical comorbidities that preclude safe participation
Active infection at or near the proposed intervention site