The primary goal of this study is to establish a database of people with varying levels of hepatic fibrosis and various etiologies of liver disease for use in future research protocols.
Subjects with known, or suspected risk factors for steatosis (fat) or hepatic fibrosis
Subjects who have been previously diagnosed with Non-Alcoholic Steatohepatitis (NASH) but who do not have current steatosis (fat) or fibrosis scoring
Subjects who have other known liver diseases ie: HCV
Patients less than 18 years of age
Pregnancy
Patients that do not want to be contacted for consideration in future research studies.
Patients diagnosed with ascites or peritoneal dialysis
* Subjects with known, or suspected risk factors for steatosis (fat) or hepatic fibrosis * Subjects who have been previously diagnosed with Non-Alcoholic Steatohepatitis (NASH) but who do not have current steatosis (fat) or fibrosis scoring * Subjects who have other known liver diseases ie: hepatitis C virus (HCV)
Case-only
Prospective
vibration controlled transient elastography (VCTE)
Procedure/SurgeryOnce on the examination table, the subject will be instructed to place the right arm under their head and to cross their right ankle over the left ankle. The subject will then be asked to slightly bend to the left side to open the intercostal space. Subsequently, a handheld probe is placed in the intercostal space overlaying the right hepatic lobe. The velocity of returning shear waves, measured at a depth of 25-65 mm, is converted into a liver stiffness measurement (LSM). The LSM obtained from a given VCTE exam is the median value of at least 10 successful measurements. This information, along with clinical data associated with the patient will be placed in a database for use in identifying potential subjects for future trials.
measurement of fibrosis in patients with varying degrees of liver disease
single event per patient with liver disease to measure degree of fibrosis concentration
measurement of liver fat in patients with varying degrees of liver disease
single event per patient with liver disease to measure degree of fat concentration
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State University of New York at Buffalo
Lead sponsor
Kaleida Health
Collaborator
