Noninvasive Elastography Evaluation of Myocardial Stiffness in Elderly Patients With Isolated Diastolic Heart Failure: New Diagnostic Tool?

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-80
SponsorFrench Cardiology Society

About this trial

The new approach propose in this protocol is based on ultrafast ultrasound and remote palpation of tissue by ultrasonic radiation pressure. Ultrafast ultrasound of biological tissues is based on an innovative ultrasound imaging approach that can image very fast soft tissue events at a rate of several thousands of frames per second and provide quantitative mapping of the elasticity of the tissues. This current project aims is to focus on myocardial rigidity in diastole to better assess the function of the heart failure.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Hospitalization in cardiology services for acute pulmonary edema during heart failure

Natriuretic peptide type B ≥35 pg/ml

Echocardiographic structural alteration

Group "preserved LVEF": Left ventricular Ejection Fraction ≥50%

Disqualifiers

Other associated lung pathology

Other heart disease

Contraindication to MRI or echocardiography gel

Pregnancy

Trial design

Design model

Single group

Treatments tested in this trial

  • SuperSonic image

    Diagnostic test

    3 examen performed assessed to compared evaluation type: Cardiac magnetic resonance imaging, standard ultrasound imaging and ultrafast imaging

Treatment groups

90 Participants
are divided into 1 treatment group
Group A: StratificationOther 1 intervention

Trial outcomes

Primary outcomes

1

Myocardial rigidity assessment

Myocardial rigidity measured using this new non-invasive ultrasound imaging technique.

Time frame
Day 1

Secondary outcomes

1

Norms estimation of myocardial rigidity

Estimation of physiological and pathological norms of myocardial rigidity by elastography

Time frame
Day 1
2

Safety of cardiac elastography

patient monitoring (electrocardiogram scope and constants every10 min) for 30 minutes post-examination associated with a "comfort questionnaire" to be completed by the patient after the examination

Time frame
Day 1

Other outcomes

Sponsors and contacts

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